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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 01-08-2021 | Metastasis | Image of the Month

[¹⁵³Sm]Samarium-labeled FAPI-46 radioligand therapy in a patient with lung metastases of a sarcoma

Authors: Clemens Kratochwil, Frederik L. Giesel, Hendrik Rathke, Rebecca Fink, Katharina Dendl, Jürgen Debus, Walter Mier, Dirk Jäger, Thomas Lindner, Uwe Haberkorn

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2021

Excerpt

Fibroblast activation protein is overexpressed by cancer-associated fibroblasts (CAFs) in the stroma of several tumor entities and provides anti-immunogenic effects [1]. It can be targeted with radiolabeled small-molecule inhibitors (FAPIs) [2]. …

Liu R, Li H, Liu L, Yu J, Ren X. Fibroblast activation protein: a potential therapeutic target in cancer. Cancer Biol Ther. 2012;13(3):123–9. https://doi.org/10.4161/cbt.13.3.18696.CrossRefPubMed

Giesel FL, Kratochwil C, Lindner T, et al. ⁶⁸Ga-FAPI PET/CT: biodistribution and preliminary dosimetry estimate of 2 DOTA-containing FAP-targeting agents in patients with various cancers. J Nucl Med. 2019;60(3):386–92. https://doi.org/10.2967/jnumed.118.215913.CrossRefPubMedPubMedCentral

Türeci Ö, Vormehr M, Diken M, Kreiter S, Huber C, Sahin U. Targeting the heterogeneity of cancer with individualized neoepitope vaccines. Clin Cancer Res. 2016;22(8):1885–96. https://doi.org/10.1158/1078-0432.CCR-15-1509.CrossRefPubMed

Ungerechts G, Engeland C, Buchholz CJ, et al. Virotherapy research in Germany: from engineering to translation. Hum Gene Ther. 2017;28(10):800–19. https://doi.org/10.1089/hum.2017.138.CrossRefPubMed

Dohi O, Ohtani H, Hatori M, Sato E, Hosaka M, Nagura H, et al. Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours. Histopathology. 2009;55(4):432–40. https://doi.org/10.1111/j.1365-2559.2009.03399.x.CrossRefPubMedPubMedCentral

Title: [153Sm]Samarium-labeled FAPI-46 radioligand therapy in a patient with lung metastases of a sarcoma
Authors: Clemens Kratochwil
Frederik L. Giesel
Hendrik Rathke
Rebecca Fink
Katharina Dendl
Jürgen Debus
Walter Mier
Dirk Jäger
Thomas Lindner
Uwe Haberkorn
Publication date: 01-08-2021
Publisher: Springer Berlin Heidelberg
Keywords: Metastasis
Soft Tissue Sarcoma
Sarcoma
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2021
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-021-05273-8

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[¹⁵³Sm]Samarium-labeled FAPI-46 radioligand therapy in a patient with lung metastases of a sarcoma

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

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