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Journal of Experimental & Clinical Cancer Research
Published in: Journal of Experimental & Clinical Cancer Research 1/2021

Open Access 01-12-2021 | Metastasis | Review

Neutrophil Extracellular Traps: A New Player in Cancer Metastasis and Therapeutic Target

Authors: Dakai Yang, Jing Liu

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2021

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Abstract

Neutrophil Extracellular Traps (NETs) are neutrophil-derived extracellular scaffolds, which typically consist of fibrous decondensed chromatins decorated with histones and granule proteins. Initially discovered as a host defence mechanism of neutrophil against pathogens, they have also been implicated in the progression of sterile inflammation-associated diseases such as autoimmune disease, diabetes, and cancer. In this review, we highlight and discuss the more recent studies on the roles of NETs in cancer development, with a special focus on cancer metastasis. Moreover, we present the strategies for targeting NETs in pre-clinical models, but also the challenging questions that need to be answered in the field.
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Metadata
Title
Neutrophil Extracellular Traps: A New Player in Cancer Metastasis and Therapeutic Target
Authors
Dakai Yang
Jing Liu
Publication date
01-12-2021
Publisher
BioMed Central
Keyword
Metastasis
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2021
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-021-02013-6

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