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Open Access 01-12-2019 | Metastasis | Case report

Successful management of cutaneous lymphangitis carcinomatosa arising from cervical cancer with paclitaxel-cisplatin and bevacizumab combination therapy: a case report and review of the literature

Authors: Fumihiro Nakamura, Manabu Seino, Yuriko Suzuki, Hirotsugu Sakaki, Takeshi Sudo, Tsuyoshi Ohta, Seiji Tsutsumi, Satoru Nagase

Published in: Journal of Medical Case Reports | Issue 1/2019

Abstract

Background

Globally, cervical cancer is the fourth most common cancer in women. Here, we report a case of cutaneous lymphangitis carcinomatosa arising from cervical cancer, an extremely rare and treatment-resistant condition.

Case presentation

A 64-year-old Japanese woman presented with genital bleeding. She was diagnosed as having stage IB1 squamous cell cervical cancer and subsequently treated with radiotherapy. Approximately 2 years after the curative radiotherapy, she developed itching, skin rash, and small nodules on her left femoral and pubic area. Slight ¹⁸F-fluorodeoxyglucose uptake was detected at her left femoral skin on positron emission tomography with computed tomography. A histopathological examination was performed on a biopsy sample from an erythematous macule on her left femoral skin and vulva. Consequently, she was diagnosed as having cutaneous lymphangitis carcinomatosa arising from cervical cancer. Paclitaxel (135 mg/m²), cisplatin (50 mg/m²), and bevacizumab (15 mg/kg) combination therapy was administered every 21 days. Both itching and rash improved after three treatment cycles. After the completion of six cycles, skin erythema in the femoral and vulval area disappeared completely. Our patient experienced a 25-month symptom-free interval after the last chemotherapy session.

Conclusion

Our findings suggest that combination chemotherapy plus bevacizumab is an effective therapeutic option in patients with cutaneous lymphangitis carcinomatosa arising from cervical cancer.

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Title: Successful management of cutaneous lymphangitis carcinomatosa arising from cervical cancer with paclitaxel-cisplatin and bevacizumab combination therapy: a case report and review of the literature
Authors: Fumihiro Nakamura
Manabu Seino
Yuriko Suzuki
Hirotsugu Sakaki
Takeshi Sudo
Tsuyoshi Ohta
Seiji Tsutsumi
Satoru Nagase
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Metastasis
Lymphangitis
Cervical Cancer
Cervical Cancer
Bevacizumab
Cytostatic Therapy
Published in: Journal of Medical Case Reports / Issue 1/2019
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-019-2262-x

At a glance: The STEP trials

Springer Medicine

Successful management of cutaneous lymphangitis carcinomatosa arising from cervical cancer with paclitaxel-cisplatin and bevacizumab combination therapy: a case report and review of the literature

Abstract

Background

Case presentation

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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