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Journal of Cancer Research and Clinical Oncology

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Open Access 21-06-2023 | Metastasis | Research

Effect of segmental versus marginal mandibular resection on local and lymph node recurrences in oral squamous cell carcinoma: is tumorous bone infiltration or location and resulting soft tissue recurrences a long-term problem?

Authors: Lucas M. Ritschl, Minli Niu, Valeriya Sackerer, Carolina Claßen, Herbert Stimmer, Andreas M. Fichter, Klaus-Dietrich Wolff, Florian D. Grill

Published in: Journal of Cancer Research and Clinical Oncology | Issue 13/2023

Abstract

Purpose

Oral squamous cell carcinomas (OSCCs) adjacent to the mandible or with clinically suspected bone infiltration are surgically treated either with marginal or segmental resections. This retrospective study compared both resections regarding local recurrence and lymph node recurrence or secondary lymph node metastases.

Methods

All consecutive primary OSCC cases between January 2007 and December 2015 that underwent mandibular marginal or segmental resection were included. Rates of local and lymph node recurrences or secondary metastases and possible risk factors such as tumor localization according to Urken’s classification were recorded.

Results

In total, 180 patients with 85 marginal (group I) and 95 segmental (group II) mandibular resections were analyzed. The local recurrence rates were comparable between the groups (28.2% vs. 27.4%; p = 0.897). Lymph node recurrences or secondary metastases were higher in group I (9.4% (n = 8) vs. 6.2% (n = 6); p = 0.001). Tumor localization appears to affect the outcomes. Significantly fewer local and lymph node recurrences/metastases were found for Urken’s classification SB and S calculated by two-proportion z-test (p = 0.014 and 0.056, respectively). Local recurrences mostly emerged from soft tissues, which should be resected more radically than the bones.

Conclusion

While bone infiltration appears technically well controllable from an oncologic point of view, local recurrences and lymph node recurrences/metastases remain an issue. Regular clinical aftercare with imaging is crucial to detect recurrences.

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Title: Effect of segmental versus marginal mandibular resection on local and lymph node recurrences in oral squamous cell carcinoma: is tumorous bone infiltration or location and resulting soft tissue recurrences a long-term problem?
Authors: Lucas M. Ritschl
Minli Niu
Valeriya Sackerer
Carolina Claßen
Herbert Stimmer
Andreas M. Fichter
Klaus-Dietrich Wolff
Florian D. Grill
Publication date: 21-06-2023
Publisher: Springer Berlin Heidelberg
Keyword: Metastasis
Published in: Journal of Cancer Research and Clinical Oncology / Issue 13/2023
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-023-04963-0

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