Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 6/2019

01-06-2019 | Metastasis | Head & Neck

Functional and oncological outcomes after retropharyngeal node dissection for papillary thyroid carcinoma

Authors: Naoki Otsuki, Naruhiko Morita, Tatsuya Furukawa, Masanori Teshima, Hitomi Shinomiya, Hirotaka Shinomiya, Ken-ichi Nibu

Published in: European Archives of Oto-Rhino-Laryngology | Issue 6/2019

Login to get access

Abstract

Background

Papillary thyroid carcinoma frequently metastasizes to central and lateral neck lymph nodes, but metastasis to retropharyngeal lymph nodes (RPLN) is rare.

Patients and methods

We retrospectively reviewed 16 patients with RPLN metastasis of PTC who underwent therapeutic dissection of RPLN metastases.

Results

Among 16 patients, 7 patients underwent RPLN dissection with initial surgery and remaining 9 patients as salvage surgery. RPLN metastasis arose unilaterally in 15 patients and bilaterally in 1 patient. Eleven patients showed temporal dysphagia and four patients showed temporal vocal cord paralysis, but both symptoms eventually recovered in all cases. Two patients with salvage RPLN dissection died of distant metastasis and six patients survived with distant metastasis and/or persistent loco-regional disease. Other eight patients have been alive without disease.

Conclusions

Although transcervical approach for RPLN metastases of PTC provided acceptable functional and oncological outcomes, half of the patients with RPLN metastasis have had distant metastasis and/or persistent locoregional disease. Indications of surgery for patients with RPLN metastasis need to be performed carefully in consideration of patients' prognosis and quality of life.
Literature
1.
McCormack KR, Sheline GE (1970) Retropharyngeal spread of carcinoma of the thyroid. Cancer 26(6):1366–1369CrossRefPubMed
2.
Robbins KT, Woodson GE (1985) Thyroid carcinoma presenting as a parapharyngeal mass. Head Neck Surg 7(5):434–436CrossRefPubMed
3.
Leger AF, Baillet G, Dagousset F, Vincenot MI, Izembart M, Clerc J, Barritault L (2000) Upper retropharyngeal node involvement in differentiated thyroid carcinoma demonstrated by 131I scintigraphy. Br J Radiol 73(876):1260–1264CrossRefPubMed
4.
Ducci M, Bozza F, Pezzuto RW, Palma L (2001) Papillary thyroid carcinoma metastatic to the parapharyngeal space. J Exp Clin Cancer Res 20(3):439–441PubMed
5.
Desuter G, Lonneux M, Plouin-Gaudon I, Jamar F, Coche E, Weynand B, Rahier J, Grégoire V, Andry G, Hamoir M (2004) Parapharyngeal metastases from thyroid cancer. Eur J Surg Oncol 30(1):80–84CrossRefPubMed
6.
Aygenc E, Kaymakci M, Karaca C, Ozdem C (2002) Papillary thyroid carcinoma metastasis to the parapharyngeal space. Eur Arch Otorhinolaryngol 259(6):322–324PubMed
7.
Otsuki N, Nishikawa T, Iwae S, Saito M, Mohri M, Nibu K (2007) Retropharyngeal node metastasis from papillary thyroid carcinoma. Head Neck 29(5):508–511CrossRefPubMed
8.
Togashi T, Sugitani I, Toda K, Kawabata K, Takahashi S (2014) Surgical management of retropharyngeal nodes metastases from papillary thyroid carcinoma. World J Surg 38(11):2831–2837CrossRefPubMed
9.
Wang XL, Xu ZG, Wu YH, Liu SY, Yu Y (2012) Surgical management of parapharyngeal lymph node metastasis of thyroid carcinoma: a retrospective study of 25 patients. Chin Med J 125(20):3635–3639PubMed
10.
Moritani S (2016) Parapharyngeal metastasis of papillary thyroid carcinoma. World J Surg 40(2):350–355CrossRefPubMed
11.
Edge SB, Greene F, Byrd DR, Brookland RK, Washington MK (2016) AJCC cancer staging manual, 8th edn. Springer, New York
12.
Perrier ND, Brierley JD, Tuttle RM (2018) Differentiated and anaplastic thyroid carcinoma: major changes in the American Joint Committee on Cancer eight edition cancer staging manual. CA Cancer J Clin 68:55–63CrossRefPubMed
13.
Lombardi D, Nicolai P, Antonelli AR, Maroldi R, Farina D, Shaha AR (2004) Parapharyngeal lymph node metastasis: an unusual presentation of papillary thyroid carcinoma. Head Neck 26(2):190–196CrossRefPubMed
14.
Ferrario F, Roselli R, Macchi A (1995) Occult thyroid carcinoma presenting as a parapharyngeal mass. J Laryngol Otol 109(12):1204–1206CrossRefPubMed
15.
Rouviere H (1967) Anatomic Humaine, Descriptive et Topograhique, 10th edn. Masson et Cie, Paris, p 506
16.
Shellenberger T, Fornage B, Ginsberg L, Clayman GL (2007) Transoral resection of thyroid cancer metastasis to lateral retropharyngeal nodes. Head Neck 29(3):258–266CrossRefPubMed
17.
Fujiwara K, Fukuhara T, Koyama S, Donishi R, Kataoka H, Kitano H, Takeuchi H (2017) Ultrasound-guided transoral videolaryngoscopic surgery for retropharyngeal lymph node metastasis of papillary thyroid cancer. Case Rep Oncol 10(2):649–655CrossRefPubMedPubMedCentral
18.
Moore MW, Jantharapattana K, Williams MD, Grant DG, Selber JC, Holsinger FC (2011) Retropharyngeal lymphadenectomy with transoral robotic surgery for papillary thyroid cancer. J Robot Surg 5(3):221CrossRefPubMed
19.
Goepfert RP, Liu C, Ryan WR (2015) Trans-oral robotic surgery and surgeon-performed trans-oral ultrasound for intraoperative location and excision of an isolated retropharyngeal lymph node metastasis of papillary thyroid carcinoma. Am J Otolaryngol 36(5):710–714CrossRefPubMed
20.
Hartl DM, Leboulleux S, Vélayoudom-Céphise FL, Mirghani H, Déandréis D, Schlumberger M (2015) Management of retropharyngeal node metastases from thyroid carcinoma. World J Surg 39(5):1274–1281CrossRefPubMed
21.
Kiess AP, Agrawal N, Brierley JD, Duvvuri U, Ferris RL, Genden E, Wong RJ, Tuttle RM, Lee NY, Randolph GW (2016) External-beam radiotherapy for differentiated thyroid cancer locoregional control: a statement of the American Head and Neck Society. Head Neck 38(4):493–498CrossRefPubMed
22.
Bernstein MB, Chang EL, Amini B, Pan H, Cabanillas M, Wang XA, Allen PK, Rhines LD, Tatsui C, Li J, Brown PD, Ghia AJ (2016) Spine stereotactic radiosurgery for patients with metastatic thyroid cancer: secondary analysis of phase I/II trials. Thyroid 26(9):1269–1275CrossRefPubMed
Metadata
Title
Functional and oncological outcomes after retropharyngeal node dissection for papillary thyroid carcinoma
Authors
Naoki Otsuki
Naruhiko Morita
Tatsuya Furukawa
Masanori Teshima
Hitomi Shinomiya
Hirotaka Shinomiya
Ken-ichi Nibu
Publication date
01-06-2019
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 6/2019
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-019-05420-w

Other articles of this Issue 6/2019

European Archives of Oto-Rhino-Laryngology 6/2019 Go to the issue

Rhinology

Correlation between olfactory function, trigeminal sensitivity, and nasal anatomy in healthy subjects

Laryngology

Exploring the feasibility of the combination of acoustic voice quality index and glottal function index for voice pathology screening

Head and Neck

Reconstruction of complex defects of the extracranial facial nerve: technique of “the trifurcation approach”

Laryngology

Laser transoral microsurgery in treatment of early laryngeal carcinoma

Otology

Prevalence and severity of tinnitus in Polish otosclerosis patients qualified for stapes surgery

Laryngology

Peritonsillar abscess is frequently accompanied by sepsis symptoms