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28-04-2023 | Metastasis | Original Article

Survival dependant upon site of colorectal cancer and timing of liver metastasis after hepatectomy

Authors: KangHe Xu, Dong Hee Ryu, Jae-Woon Choi, Hanlim Choi

Published in: Indian Journal of Surgery | Issue 1/2024

Abstract

Factors affecting overall survival (OS) after hepatectomy for colorectal cancer liver metastases (CRCLM) are unknown. This study aimed to investigate the effect of the location of the primary tumor and the timing of liver metastases on OS in patients with CRCLM who underwent hepatectomy. Patients with CRCLM who underwent hepatectomy between August 2005 and December 2019 were retrospectively enrolled in this study, at our institution. In total, 87 patients with CRCLM who underwent hepatectomy were included in this study. The primary tumor was located on the right and left sides in 27 (31%) and 60 (69%) patients, respectively. A total of 53 (61%) and 34 (39%) patients had synchronous and metachronous liver metastases, respectively. The median OS period for all patients was 31 (interquartile range [IQR], 21.3–40.7) months. The median OS periods in the right and left-sided groups were 26 (IQR, 11.7–40.3) and 32 (IQR, 23.1–40.8) months, respectively. There was no significant difference between the two groups. The median OS periods for the synchronous and metachronous groups were 26 (IQR, 21.5–30.5) and 76 (IQR, 28.2–123.8; P = 0.001) months, respectively. Cox proportional hazards model analysis showed that synchronous liver metastases were associated with poorer OS. The hazard ratio was 2.405 (95% confidence interval, 1.364–4.240; P = 0.002) Primary tumor location has no effect on OS after hepatectomy in patients with CRCLM. Synchronous liver metastases are associated with poorer OS after hepatectomy in patients with CRCLM.

Siegel RL, Miller KD, Fedewa SA et al (2017) Colorectal cancer statistics, 2017. CA Cancer J Clin 67:177–193. https://doi.org/10.3322/caac.21395CrossRefPubMed

Brouwer NPM, van der Kruijssen DEW, Hugen N et al (2020) The Impact of Primary Tumor Location in Synchronous Metastatic Colorectal Cancer: Differences in Metastatic Sites and Survival. Ann Surg Oncol 27:1580–1588. https://doi.org/10.1245/s10434-019-08100-5CrossRefPubMed

Vellinga TT, Kranenburg O, Frenkel N et al (2017) Lymphangiogenic Gene Expression Is Associated With Lymph Node Recurrence and Poor Prognosis After Partial Hepatectomy for Colorectal Liver Metastasis. Ann Surg 266:765–771. https://doi.org/10.1097/SLA.0000000000002430CrossRefPubMed

Sasaki K, Andreatos N, Margonis GA et al (2016) The prognostic implications of primary colorectal tumor location on recurrence and overall survival in patients undergoing resection for colorectal liver metastasis. J Surg Oncol 114:803–809. https://doi.org/10.1002/jso.24425CrossRefPubMed

Dupre A, Malik HZ, Jones RP, Diaz-Nieto R, Fenwick SW, Poston GJ (2018) Influence of the primary tumour location in patients undergoing surgery for colorectal liver metastases. Eur J Surg Oncol 44:80–86. https://doi.org/10.1016/j.ejso.2017.10.218CrossRefPubMed

Wang K, Xu D, Yan XL, Poston G, Xing BC (2018) The impact of primary tumour location in patients undergoing hepatic resection for colorectal liver metastasis. Eur J Surg Oncol 44:771–777. https://doi.org/10.1016/j.ejso.2018.02.210CrossRefPubMed

Makowiec F, Menzel M, Bronsert P et al (2018) Does the site of primary colorectal cancer influence the outcome after resection of isolated liver metastases? Dig Liver Dis 50:1088–1092. https://doi.org/10.1016/j.dld.2018.06.019CrossRefPubMed

Okholm C, Mollerup TK, Schultz NA, Strandby RB, Achiam MP (2018) Synchronous and metachronous liver metastases in patients with colorectal cancer. Dan Med J 65

Engstrand J, Stromberg C, Nilsson H, Freedman J, Jonas E (2019) Synchronous and metachronous liver metastases in patients with colorectal cancer-towards a clinically relevant definition. World J Surg Oncol 17:228. https://doi.org/10.1186/s12957-019-1771-9CrossRefPubMedPubMedCentral

10.

Weiser MR (2018) AJCC 8th Edition: Colorectal Cancer. Ann Surg Oncol 25:1454–1455. https://doi.org/10.1245/s10434-018-6462-1CrossRefPubMed

11.

Gasser E, Braunwarth E, Riedmann M et al (2019) Primary tumour location affects survival after resection of colorectal liver metastases: A two-institutional cohort study with international validation, systematic meta-analysis and a clinical risk score. PLoS One 14:e0217411. https://doi.org/10.1371/journal.pone.0217411CrossRefPubMedPubMedCentral

12.

Tomlinson JS, Jarnagin WR, DeMatteo RP et al (2007) Actual 10-year survival after resection of colorectal liver metastases defines cure. J Clin Oncol 25:4575–4580. https://doi.org/10.1200/JCO.2007.11.0833CrossRefPubMed

13.

Creasy JM, Sadot E, Koerkamp BG et al (2018) The Impact of Primary Tumor Location on Long-Term Survival in Patients Undergoing Hepatic Resection for Metastatic Colon Cancer. Ann Surg Oncol 25:431–438. https://doi.org/10.1245/s10434-017-6264-xCrossRefPubMed

14.

Price TJ, Beeke C, Ullah S et al (2015) Does the primary site of colorectal cancer impact outcomes for patients with metastatic disease? Cancer 121:830–835. https://doi.org/10.1002/cncr.29129CrossRefPubMed

15.

Zhang Y, Wang Y, Yuan Y et al (2020) Primary tumor location affects recurrence-free survival for patients with colorectal liver metastases after hepatectomy: a propensity score matching analysis. World J Surg Oncol 18:98. https://doi.org/10.1186/s12957-020-01875-yCrossRefPubMedPubMedCentral

16.

Liu W, Wang HW, Wang K, Xing BC (2019) The primary tumor location impacts survival outcome of colorectal liver metastases after hepatic resection: A systematic review and meta-analysis. Eur J Surg Oncol 45:1349–1356. https://doi.org/10.1016/j.ejso.2019.04.017CrossRefPubMed

17.

van der Geest LG, Lam-Boer J, Koopman M, Verhoef C, Elferink MA, de Wilt JH (2015) Nationwide trends in incidence, treatment and survival of colorectal cancer patients with synchronous metastases. Clin Exp Metastasis 32:457–465. https://doi.org/10.1007/s10585-015-9719-0CrossRefPubMed

18.

Vayrynen V, Wirta EV, Seppala T et al (2020) Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases: a population-based study. BJS Open 4:685–692. https://doi.org/10.1002/bjs5.50299CrossRefPubMedPubMedCentral

19.

Garajova I, Balsano R, Tommasi C, et al (2020) Synchronous and metachronous colorectal liver metastases: impact of primary tumor location on patterns of recurrence and survival after hepatic resection. Acta Biomed 92:e2021061. https://doi.org/10.23750/abm.v92i1.11050

20.

Colloca GA, Venturino A, Guarneri D (2020) Different variables predict the outcome of patients with synchronous versus metachronous metastases of colorectal cancer. Clin Transl Oncol 22:1399–1406. https://doi.org/10.1007/s12094-019-02277-7CrossRefPubMed

21.

Willem H, Jooste V, Boussari O, Romain G, Bouvier AM (2019) Impact of absence of consensual cutoff time distinguishing between synchronous and metachronous metastases: illustration with colorectal cancer. Eur J Cancer Prev 28:167–172. https://doi.org/10.1097/CEJ.0000000000000450CrossRefPubMed

22.

Quireze Junior C, Brasil AMS, Morais LK, Campion ERL, Taveira EJF, Rassi MC (2018) Metachronous Colorectal Liver Metastases Has Better Prognosis - Is It True? Arq Gastroenterol 55:258–263. https://doi.org/10.1590/S0004-2803.201800000-64CrossRefPubMed

23.

Mekenkamp LJ, Koopman M, Teerenstra S et al (2010) Clinicopathological features and outcome in advanced colorectal cancer patients with synchronous vs metachronous metastases. Br J Cancer 103:159–164. https://doi.org/10.1038/sj.bjc.6605737CrossRefPubMedPubMedCentral

24.

Kuo IM, Huang SF, Chiang JM et al (2015) Clinical features and prognosis in hepatectomy for colorectal cancer with centrally located liver metastasis. World J Surg Oncol 13:92. https://doi.org/10.1186/s12957-015-0497-6CrossRefPubMedPubMedCentral

25.

Lan YT, Chang SC, Lin PC et al (2021) Clinicopathological and molecular features between synchronous and metachronous metastases in colorectal cancer. Am J Cancer Res 11:1646–1658PubMedPubMedCentral

26.

Pantaleo MA, Astolfi A, Nannini M et al (2008) Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice. Br J Cancer 99:1729–1734. https://doi.org/10.1038/sj.bjc.6604681CrossRefPubMedPubMedCentral

Title: Survival dependant upon site of colorectal cancer and timing of liver metastasis after hepatectomy
Authors: KangHe Xu
Dong Hee Ryu
Jae-Woon Choi
Hanlim Choi
Publication date: 28-04-2023
Publisher: Springer India
Keywords: Metastasis
Colorectal Cancer
Colorectal Cancer
Published in: Indian Journal of Surgery / Issue 1/2024
Print ISSN: 0972-2068
Electronic ISSN: 0973-9793
DOI: https://doi.org/10.1007/s12262-023-03790-4

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Survival dependant upon site of colorectal cancer and timing of liver metastasis after hepatectomy

Abstract

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Abstract

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