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01-09-2021 | Metastasis | Original Article

Preoperative Lymphocyte-to-Monocyte Ratio in the Prognostication of Advanced Resectable Colon Cancer: a Retrospective Observational Study

Authors: Kenta Kasahara, Tetsuo Ishizaki, Masanobu Enomoto, Junichi Mazaki, Naoto Okazaki, Tomoya Tago, Ryutaro Udo, Yuichi Nagakawa, Kenji Katsumata, Akihiko Tsuchida

Published in: Indian Journal of Surgical Oncology | Issue 3/2021

Abstract

Lymphocyte-to-monocyte ratio (LMR) has been reported as a biomarker for predicting the prognosis of colorectal cancer. However, the clinical usefulness of LMR requires detailed research, which can contribute to better therapeutic strategies. A cohort of 554 patients with resectable advanced colon cancer in our institution was analyzed retrospectively. An analysis of stages II and III resectable advanced colon cancer was performed. LMR was useful for predicting overall survival (OS) and relapse-free survival (RFS). The ROC curve revealed an LMR value of 2.77 as a cutoff for OS. A high LMR was an independent prognostic factor and was associated with a high hazard ratio (HR) in all cases for OS (HR = 0.530, 95% confidence interval (CI) = 0.334–0.842, p = 0.007). A high LMR was not an independent prognostic factor in stage II cases but was a predictor with the strongest association with prognosis in patients with stage III cases for OS (HR = 0.383, 95% CI = 0.160–0.915, p = 0.031). LMR is a strong predictor of prognosis in patients with stage III colon cancer and may be useful in postoperative treatment options.

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Title: Preoperative Lymphocyte-to-Monocyte Ratio in the Prognostication of Advanced Resectable Colon Cancer: a Retrospective Observational Study
Authors: Kenta Kasahara
Tetsuo Ishizaki
Masanobu Enomoto
Junichi Mazaki
Naoto Okazaki
Tomoya Tago
Ryutaro Udo
Yuichi Nagakawa
Kenji Katsumata
Akihiko Tsuchida
Publication date: 01-09-2021
Publisher: Springer India
Keywords: Metastasis
Colon Cancer
Colon Cancer
Colorectal Cancer
Colorectal Cancer
Published in: Indian Journal of Surgical Oncology / Issue 3/2021
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI: https://doi.org/10.1007/s13193-021-01356-y

At a glance: The STEP trials

Springer Medicine

Preoperative Lymphocyte-to-Monocyte Ratio in the Prognostication of Advanced Resectable Colon Cancer: a Retrospective Observational Study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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