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Annals of Surgical Oncology

30-04-2024 | Metastasis | Peritoneal Surface Malignancy

Value of Surgical Cytoreduction in Patients with Small Intestinal Neuroendocrine Tumors Metastatic to the Liver and Peritoneum

Authors: Hallbera Gudmundsdottir, MD, Alessandro Fogliati, MD, Travis E. Grotz, MD, Cornelius A. Thiels, DO, Susanne G. Warner, MD, Rory L. Smoot, MD, Mark J. Truty, MD, Michael L. Kendrick, MD, David M. Nagorney, MD, Thorvardur R. Halfdanarson, MD, Sean P. Cleary, MD, Patrick Starlinger, MD

Published in: Annals of Surgical Oncology

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Abstract

Background

Cytoreductive hepatectomy can improve survival and symptoms of hormonal excess in patients with small intestinal neuroendocrine tumor (siNET) liver metastases, but whether to proceed when peritoneal metastases are encountered at the time of planned cytoreductive hepatectomy is controversial.

Methods

This was a retrospective review of patients who underwent surgical management of metastatic siNETs at Mayo Clinic between 2000 and 2020. Patients who underwent cytoreductive operation for isolated liver metastases or both liver and peritoneal metastases were compared.

Results

Of 261 patients who underwent cytoreductive operation for siNETs, 211 had isolated liver metastases and 50 had liver and peritoneal metastases. Complete cytoreduction was achieved in 78% of patients with isolated liver metastases and 56% of those with liver and peritoneal metastases (p = 0.002). After complete cytoreduction, median overall survival (OS) was 11.5 years for isolated liver metastases and 11.2 years for liver and peritoneal metastases (p = 0.10), and relief of carcinoid syndrome was ≥ 97% in both groups. After incomplete cytoreduction with debulking of > 90% of hepatic disease and/or closing Lyon score of 1–2, median OS was 6.4 years for isolated liver metastases and 7.1 years for liver and peritoneal metastases (p = 0.12).

Conclusions

Patients with siNETs metastatic to both the liver and peritoneum have favorable outcomes after aggressive surgical cytoreduction, with the best outcomes observed after complete cytoreduction. Therefore, the presence of peritoneal metastases should not by itself preclude surgical cytoreduction in this population.
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Metadata
Title
Value of Surgical Cytoreduction in Patients with Small Intestinal Neuroendocrine Tumors Metastatic to the Liver and Peritoneum
Authors
Hallbera Gudmundsdottir, MD
Alessandro Fogliati, MD
Travis E. Grotz, MD
Cornelius A. Thiels, DO
Susanne G. Warner, MD
Rory L. Smoot, MD
Mark J. Truty, MD
Michael L. Kendrick, MD
David M. Nagorney, MD
Thorvardur R. Halfdanarson, MD
Sean P. Cleary, MD
Patrick Starlinger, MD
Publication date
30-04-2024
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-024-15316-7