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BMC Surgery
Published in: BMC Surgery 1/2023

Open Access 01-12-2023 | Metastasis | Research

Clinicopathological characteristics of rectal multiple neuroendocrine neoplasms and literature review

Authors: Xiuli Zheng, Mingli Wu, Shengmian Li, Limian Er, Huiyan Deng, Shuo Guo, Zhihuan Liu

Published in: BMC Surgery | Issue 1/2023

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Abstract

Background

There are only a few epidemiological reports available for reference. The clinicopathological features are not clear, so there is no consensus on treating rectal multiple neuroendocrine neoplasms. This study aims to summarize the clinicopathological characteristics and preliminarily discuss the clinical diagnosis and treatment of rectal multiple neuroendocrine neoplasms.

Methods

This study retrospectively analyzed rectal neuroendocrine neoplasm patients diagnosed and treated at the Fourth Hospital of Hebei Medical University from February 2007 to May 2021. The clinicopathological characteristics of rectal multiple neuroendocrine neoplasms were summarized and analyzed in combination with 14 studies on rectal multiple neuroendocrine neoplasms.

Results

The incidence of RM-NENs accounted for 3.8% of all R-NENs in this study. The number of tumors varied to some extent, the size of tumors was basically no more than 10 mm, and there were more G1 grade tumors. In the analysis of 46 cases with known lymph node metastasis, the difference in lymph node metastasis rate between the number of tumors < 8 and ≥ 8 was statistically significant (p = 0.002).

Conclusions

The incidence of rectal multiple neuroendocrine neoplasms accounted for 3.8% of all rectal neuroendocrine neoplasms. For rectal multiple neuroendocrine neoplasms, the lymph node metastasis rate was higher when the number of tumors was ≥ 8. The influence of the number of tumors on lymph node metastasis should be considered in the selection of treatment.
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Metadata
Title
Clinicopathological characteristics of rectal multiple neuroendocrine neoplasms and literature review
Authors
Xiuli Zheng
Mingli Wu
Shengmian Li
Limian Er
Huiyan Deng
Shuo Guo
Zhihuan Liu
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Surgery / Issue 1/2023
Electronic ISSN: 1471-2482
DOI
https://doi.org/10.1186/s12893-023-02050-2

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