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01-12-2020 | Metastasis | ASO Author Reflections

ASO Author Reflections: MicroRNA-Based Nomogram for Prediction of Sentinel Lymph Node Metastasis in ER+/HER2− Breast Cancer in Hoping for a Possible Omission of Sentinel Lymph Node Biopsy

Authors: Jun Okuno, MD, Tomohiro Miyake, MD, Kenzo Shimazu, MD, Shinzaburo Noguchi, MD

Published in: Annals of Surgical Oncology | Special Issue 3/2020

Excerpt

Sentinel lymph node biopsy (SLNB) is established as a less invasive axillary staging method than axillary lymph node dissection for clinically node-negative breast cancer patients. Nevertheless, SLNB is not free from comorbidities, including lymphedema and neuropathy, to some extent.1 Thus, attempts have been made to develop a model to predict sentinel lymph node metastasis (SLNM), such as the MSKCC nomogram and gene profiling analysis, for the purpose of selecting patients who are at a very low risk of SLNM and thus in whom SLNB can be omitted.2,3 However, the accuracy of these predictors seems insufficient for routine clinical use. …

Galimberti V, Cole BF, Viale G, et al. Axillary dissection versus no axillary dissection in patients with breast cancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomised, controlled phase 3 trial. Lancet Oncol. 2018;19(10):1385–93.CrossRef

Bevilacqua JL, Kattan MW, Fey JV, Cody HS 3rd, Borgen PI, Van Zee KJ. Doctor, what are my chances of having a positive sentinel node? A validated nomogram for risk estimation. J Clin Oncol. 2007;25(24):3670–9.CrossRef

Nakauchi C, Naoi Y, Shimazu K, et al. Development of a prediction model for lymph node metastasis in luminal A subtype breast cancer: the possibility to omit sentinel lymph node biopsy. Cancer Lett. 2014;353(1):52–8.CrossRef

Okuno J, Miyake T, Sota Y, et al. Development of prediction model including microRNA expression for sentinel lymph node metastasis in ER-positive and HER2-negative breast cancer. Ann Surg Oncol. 2020. https://doi.org/10.1245/s10434-020-08735-9.CrossRefPubMed

Title: ASO Author Reflections: MicroRNA-Based Nomogram for Prediction of Sentinel Lymph Node Metastasis in ER+/HER2− Breast Cancer in Hoping for a Possible Omission of Sentinel Lymph Node Biopsy
Authors: Jun Okuno, MD
Tomohiro Miyake, MD
Kenzo Shimazu, MD
Shinzaburo Noguchi, MD
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Metastasis
Breast Cancer
Breast Cancer
Published in: Annals of Surgical Oncology / Issue Special Issue 3/2020
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-020-08797-9

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ASO Author Reflections: MicroRNA-Based Nomogram for Prediction of Sentinel Lymph Node Metastasis in ER+/HER2− Breast Cancer in Hoping for a Possible Omission of Sentinel Lymph Node Biopsy

Excerpt

Keynote webinar | Spotlight on medication adherence

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