Published in:
03-02-2024 | Metastasis | ASO Author Reflections
ASO Author Reflections: Surgical Technique for Colorectal Liver Metastases: Biology is King, but the Princes and Princesses (Surgical Techniques) also Matter
Authors:
Emmanouil Pikoulis, MD, PhD, Katharina Beyer, MD, Martin E. Kreis, MD, Timothy M. Pawlik, MD, MPH, PhD, Georgios Antonios Margonis, MD, PhD
Published in:
Annals of Surgical Oncology
|
Issue 6/2024
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Excerpt
Several studies have sought to determine the optimal surgical technique (anatomic versus nonanatomic hepatectomy) to treat colorectal liver metastases (CRLM), but the results have been inconsistent.
1 One potential explanation for this variability is that the impact of anatomic versus nonanatomic hepatectomy may depend on the tumor’s biology. This notion was initially proposed in a 2017 study conducted at Johns Hopkins, which revealed that patients with
RAS-mutated CRLM benefited from anatomic hepatectomies, while individuals with
RAS wild-type tumors did not.
2 These data attracted the attention of the surgical and scientific community, and similar studies were conducted by other groups, although with disparate results. We hypothesized that the divergent findings could be attributed to the limited statistical power of prior studies. As such, we sought to synthesize the results from each study to enhance statistical power and provide a more comprehensive understanding of the relationship between surgical techniques and CRLM outcomes in the context of distinct tumor biology. …
