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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2020

01-12-2020 | Metastasis | ASO Author Reflections

ASO Author Reflections: Implementation of a New Hepatic Artery Infusion Program for Colorectal Liver Metastases is Safe, Feasible, and Effective

Authors: John M. Creasy, MD, Michael E. Lidsky, MD

Published in: Annals of Surgical Oncology | Issue 13/2020

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Excerpt

Hepatic artery infusion (HAI) combined with systemic chemotherapy is a treatment strategy for unresectable liver-only or liver-dominant colorectal liver metastases (CRLM). A single-center, randomized trial demonstrated the utility of HAI, and a recent prospective study reported response rates to concurrent HAI and chemotherapy of 76%.1,2 HAI is also efficacious for patients refractory to systemic chemotherapy, resulting in remarkable hepatic disease control rates (DCRs) compared with subsequent chemotherapeutic regimens.3 However, HAI has unique complications and requires an experienced team to optimize patient selection and safely deliver therapy.4 Thus, HAI has been performed at only a few specialized centers, and it remains unclear whether it can be safely introduced and the results replicated at other tertiary referral hospitals. …
Literature
1.
D'Angelica MI, Correa-Gallego C, Paty PB, et al. Phase II trial of hepatic artery infusional and systemic chemotherapy for patients with unresectable hepatic metastases from colorectal cancer: conversion to resection and long-term outcomes. Ann Surg 2015;261(2):353-60.CrossRef
2.
Kemeny NE, Niedzwiecki D, Hollis DR, et al. Hepatic arterial infusion versus systemic therapy for hepatic metastases from colorectal cancer: a randomized trial of efficacy, quality of life, and molecular markers (CALGB 9481). J Clin Oncol 2006;24(9):1395-403.CrossRef
3.
Cercek A, Boucher TM, Gluskin JS, et al. Response rates of hepatic arterial infusion pump therapy in patients with metastatic colorectal cancer liver metastases refractory to all standard chemotherapies. J Surg Oncol 2016;114(6):655-663.CrossRef
4.
Allen PJ, Nissan A, Picon AI, et al. Technical complications and durability of hepatic artery infusion pumps for unresectable colorectal liver metastases: an institutional experience of 544 consecutive cases. J Am Coll Surg 2005;201(1):57-65.CrossRef
5.
Creasy JM, Napier KJ, Reed SA, et al. Implementation of a hepatic artery infusion program: initial patient selection and perioperative outcomes of concurrent HAI and systemic chemotherapy for colorectal liver metastases. Ann Surg Oncol. 2020. https://​doi.​org/​10.​1245/​s10434-020-08972-y.
Metadata
Title
ASO Author Reflections: Implementation of a New Hepatic Artery Infusion Program for Colorectal Liver Metastases is Safe, Feasible, and Effective
Authors
John M. Creasy, MD
Michael E. Lidsky, MD
Publication date
01-12-2020
Publisher
Springer International Publishing
Keyword
Metastasis
Published in
Annals of Surgical Oncology / Issue 13/2020
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-020-09040-1

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