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Annals of Surgical Oncology

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23-05-2022 | Metastasis | Sarcoma

Application of Endoprosthetic Replacement in Old Patients with Isolated Proximal Femoral Bone Metastases

Authors: Peng Liu, MD, PhD, Zhuan Wang, MD, Shiyuan Zhang, MD, Guoqiang Ding, MD, Ke Tan, MD, Ji Zhou, MD

Published in: Annals of Surgical Oncology | Issue 13/2022

Abstract

Background

Due to radical resection, endoprosthetic reconstruction (EPR) is more invasive and increases the risk of dislocation. Therefore, the suitability of EPR for elderly patients with metastatic tumor needs further investigation.

Methods

Seventy-one adult patients with isolated proximal femoral bone metastases who underwent EPR were retrospectively analyzed and stratified into two groups: elderly age group (≥60 years, n = 31) and younger age group (<60 years, n = 40). The effect of age on prognosis was analyzed to determine whether EPR is beneficial in elderly patients with proximal femoral metastatic tumor. Cox regression modeling was used to evaluate the effect of different factors on postoperative survival outcomes.

Results

Ten (32.26%) and 9 (22.50%) cases of perioperative complications were recorded in the elderly and younger age groups, respectively, with median survival times of 22.00 ± 4.61 months and 23.00 ± 2.85 months, respectively; a log-rank test showed that the difference was not statistically significant (p = 0.657). A Cox regression model was established with patient age as the covariable to evaluate whether it affected postoperative survival. The risk of death due to age was not significant (p = 0.649), but malignancy and femoral metastasis type were significantly associated with postoperative survival (p = 0.001 and p = 0.019).

Conclusion

Although older patients have a slightly higher incidence of postoperative complications than younger patients, they do not experience severe adverse consequences. With rigorous selection and careful preparation, EPR is appropriate for the treatment of proximal femoral metastases in older patients, including those with Harrington type I–II acetabular invasion.

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Title: Application of Endoprosthetic Replacement in Old Patients with Isolated Proximal Femoral Bone Metastases
Authors: Peng Liu, MD, PhD
Zhuan Wang, MD
Shiyuan Zhang, MD
Guoqiang Ding, MD
Ke Tan, MD
Ji Zhou, MD
Publication date: 23-05-2022
Publisher: Springer International Publishing
Keyword: Metastasis
Published in: Annals of Surgical Oncology / Issue 13/2022
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-022-11912-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Application of Endoprosthetic Replacement in Old Patients with Isolated Proximal Femoral Bone Metastases

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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