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Open Access 01-12-2007 | Research article

Metabolic profiling of human brain metastases using in vivo proton MR spectroscopy at 3T

Authors: Torill E Sjøbakk, Roar Johansen, Tone F Bathen, Ursula Sonnewald, Kjell A Kvistad, Steinar Lundgren, Ingrid S Gribbestad

Published in: BMC Cancer | Issue 1/2007

Abstract

Background

Metastases to the central nervous system from different primary cancers are an oncologic challenge as the overall prognosis for these patients is generally poor. The incidence of brain metastases varies with type of primary cancer and is probably increasing due to improved therapies of extracranial metastases prolonging patient's overall survival and thereby time for brain metastases to develop. In addition, the greater access to improved neuroimaging techniques can provide earlier diagnosis. The aim of this study was to investigate the feasibility of using proton magnetic resonance spectroscopy (MRS) and multivariate analyses to characterize brain metastases originating from different primary cancers, to assess changes in spectra during radiation treatment and to correlate the spectra to clinical outcome after treatment.

Methods

Patients (n = 26) with brain metastases were examined using single voxel MRS at a 3T clinical MR system. Five patients were excluded due to poor spectral quality. The spectra were obtained before start (n = 21 patients), immediately after (n = 6 patients) and two months after end of treatment (n = 4 patients). Principal component analysis (PCA) and partial least square regression analysis (PLS) were applied in order to identify clustering of spectra due to origin of metastases and to relate clinical outcome (survival) of the patients to spectral data from the first MR examination.

Results

The PCA results indicated that brain metastases from primary lung and breast cancer were separated into two clusters, while the metastases from malignant melanomas showed no uniformity. The PLS analysis showed a significant correlation between MR spectral data and survival five months after MRS before start of treatment.

Conclusion

MRS determined metabolic profiles analysed by PCA and PLS might give valuable clinical information when planning and evaluating the treatment of brain metastases, and also when deciding to terminate further therapies.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/7/141/prepub

Title: Metabolic profiling of human brain metastases using in vivo proton MR spectroscopy at 3T
Authors: Torill E Sjøbakk
Roar Johansen
Tone F Bathen
Ursula Sonnewald
Kjell A Kvistad
Steinar Lundgren
Ingrid S Gribbestad
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2007
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/1471-2407-7-141

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