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Endocrine
Published in: Endocrine 2/2013

01-10-2013 | Original Article

Metabolic fuel utilization and subclinical atherosclerosis in overweight/obese subjects

Authors: Tiziana Montalcini, Carmine Gazzaruso, Yvelise Ferro, Valeria Migliaccio, Stefania Rotundo, Alberto Castagna, Arturo Pujia

Published in: Endocrine | Issue 2/2013

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Abstract

The utilization of different macronutrients is relevant for the risk of obesity, diabetes, or the appearing of vascular complications. The Respiratory Quotient (RQ) is a parameter measuring the fuel utilizations; in fact, it can indicate the fat stores utilization or lipogenesis activation. Aim of this study was to investigate the link between the RQ and the subclinical carotid atherosclerosis presence in overweight/obese subjects. 132 subjects with body mass index at least 25, at conventional diet, underwent an Indirect Calorimetry for the measurement of the Resting Metabolic Rate as well as the RQ and an evaluation of carotid arteries with ultrasound. Biochemical analyses were also performed. The mean age was 48 ± 12 years. There was a positive relation between carotid intima-media thickness and RQ (p = 0.010), with the high value in the subgroup with high RQ (p = 0.045 vs. group with low RQ). The RQ, an index of fuel utilization, is positively associated to subclinical carotid atherosclerosis in overweight/obese individuals.
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Metadata
Title
Metabolic fuel utilization and subclinical atherosclerosis in overweight/obese subjects
Authors
Tiziana Montalcini
Carmine Gazzaruso
Yvelise Ferro
Valeria Migliaccio
Stefania Rotundo
Alberto Castagna
Arturo Pujia
Publication date
01-10-2013
Publisher
Springer US
Published in
Endocrine / Issue 2/2013
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-012-9845-2

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