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International Journal of Pediatric Endocrinology
Published in: International Journal of Pediatric Endocrinology 1/2011

Open Access 01-12-2011 | Research

Metabolic control and bone health in adolescents with type 1 diabetes

Authors: Jill H Simmons, Miranda Raines, Kathryn D Ness, Randon Hall, Tebeb Gebretsadik, Subburaman Mohan, Anna Spagnoli

Published in: International Journal of Pediatric Endocrinology | Issue 1/2011

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Abstract

Background

Adults with type 1 diabetes (T1D) have decreased bone mineral density (BMD) and increased fracture risk, yet the etiologies remain elusive. Early detection of derangements in bone biomarkers during adolescence could lead to timely recognition. In adolescents with T1D, we evaluated the relationships between metabolic control, BMD, and bone anabolic and turnover markers.

Methods

Cross-sectional study of 57 adolescent subjects with T1D who had HbA1c consistently ≥ 9% (Poor Control, PC n = 27) or < 9% (Favorable Control, FC n = 30) for two years prior to enrollment. Subjects had T1DM for at least three years and were without diabetes complications, known celiac disease, or other chronic diseases.

Results

There were no differences between HbA1c groups in BMD, components of the IGF system, or 25-hydroxyvitamin D status. The prevalence of 25-hydroxyvitamin D abnormalities was similar to that seen in the general adolescent population. Few patients met the recommended dietary allowance (RDA) for vitamin D or calcium.

Conclusions

These data provide no evidence of association between degree of metabolic control and BMD in adolescents with T1D. Adolescents with T1D have a high prevalence of serum 25-hydroxyvitamin D abnormalities. Longitudinal studies are needed to evaluate the predictive value of vitamin D abnormalities on fracture risk.
Appendix
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Metadata
Title
Metabolic control and bone health in adolescents with type 1 diabetes
Authors
Jill H Simmons
Miranda Raines
Kathryn D Ness
Randon Hall
Tebeb Gebretsadik
Subburaman Mohan
Anna Spagnoli
Publication date
01-12-2011
Publisher
BioMed Central
Published in
International Journal of Pediatric Endocrinology / Issue 1/2011
Electronic ISSN: 1687-9856
DOI
https://doi.org/10.1186/1687-9856-2011-13

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