Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Breast Cancer Research
Published in: Breast Cancer Research 2/2007

01-12-2007 | Short communication

Metabolic approaches to breast cancer treatment and prevention

Author: Anthony Howell

Published in: Breast Cancer Research | Special Issue 2/2007

Login to get access

Excerpt

Standard systemic therapy for breast cancer treatment and prevention are generally directed at reduction in cell growth and increase in apoptosis by direct inhibition of DNA synthesis or signalling pathways that control cell proliferation and cell death. Data are accumulating that calorie restriction (CR) and/or exercise, or agents that target metabolic pathways may have antitumour effects either alone or in combination with standard therapies for cancer prevention and treatment, and merit further investigation. Here, we outline evidence concerning the effectiveness of this approach. …
Literature
1.
Moreschi C: Beziehungen zwischen ernährung und tumorwachstum. Z Immunitätsforsch Orig. 1909, 2: 651-675.
2.
Dirx MJ, Zeegers MP, Dagnelie PC, van den Bogaard T, van den Brandt PA: Energy restriction and the risk of spontenous mammary tumors in mice: a meta-analysis. Int J Cancer. 2003, 106: 766-770. 10.1002/ijc.11277.CrossRefPubMed
3.
Harvie M, Howell A, Vierkant RA, Kumar N, Cerhan JR, Kelemen LE, Folsom AR, Sellers TA: Association of gain and loss of weight before and after menopause with risk of postmenopausal breast cancer in the lowa women's health study. Cancer Epidemiol Biomarkers Prev. 2005, 14: 656-661. 10.1158/1055-9965.EPI-04-0001.CrossRefPubMed
4.
Eliassen AH, Colditz GA, Rosner B, Willett WC, Hankinson SE: Adult weight change and risk of postmenopausal breast cancer. JAMA. 2006, 296: 193-201. 10.1001/jama.296.2.193.CrossRefPubMed
5.
Kroenke CH, Fung TT, Hu FB, Holmes MD: Dietary patterns and survival after breast cancer diagnosis. J Clin Oncol. 2005, 23: 9295-9303. 10.1200/JCO.2005.02.0198.CrossRefPubMed
6.
Chlebowski RT, Blackburn GL, Thomson CA, Nixon DW, Shapiro A, Hoy MK, Goodman MT, Giuliano AE, Karanja N, McAndrew P, et al: Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study. J Natl Cancer Inst. 2006, 98: 1767-1776.CrossRefPubMed
7.
Cleary MP, Jacobson MK, Phillips FC, Getzin SC, Grande JP, Maihle NJ: Weight-cycling decreases incidence and increases latency of mammary tumors to a greater extent than does chronic caloric restriction in mouse mammary tumor virus-transforming growth factor-alpha female mice. Cancer Epidemiol Biomarkers Prev. 2002, 11: 836-843.PubMed
8.
Lane MA, Roth GS, Ingram DK: Caloric restriction mimetics: a novel approach for biogerontology. Methods Mol Biol. 2007, 371: 1143-1149.
9.
Thompson HJ, Zhu Z, Jiang W: Dietary energy restriction in breast cancer prevention. Mammary Gland Biol Neoplasia. 2003, 8: 133-142. 10.1023/A:1025743607445.CrossRef
10.
Warburg O: On the origin of cancer cells. Science. 1956, 123: 309-314. 10.1126/science.123.3191.309.CrossRefPubMed
11.
Medes G, Thomas A, Weinhouse S: Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res. 1953, 13: 27-29.PubMed
12.
Modica-Napolitano JS, Kulawiec M, Singh KK: Mitochondria and human cancer. Curr Mol Med. 2007, 7: 121-131. 10.2174/156652407779940495.CrossRefPubMed
13.
Hardie DG: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol. 2007, 8: 774-785. 10.1038/nrm2249.CrossRefPubMed
14.
Kondoh H, Lieonart ME, Gil J, Wang J, Degan P, Peters G, Martinez D, Carnero A, Beach D: Glycolytic enzymes can modulate cellular life span. Cancer Res. 2005, 65: 177-185.PubMed
15.
Zhu Z, Jiang W, McGinley JN, Thompson HJ: 2-Deoxyglucose as an energy restriction mimetic agent: effects of mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Re. 2005, 65: 7023-7300. 10.1158/0008-5472.CAN-05-0453.CrossRef
16.
Zhou W, Han WF, Landree LE, Thupari JN, Pinn ML, Bililign T, Kim EK, Vadlamudi A, Medghalchi SM, El Meskini R, et al: Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. Cancer Res. 2007, 67: 2964-2971. 10.1158/0008-5472.CAN-06-3439.CrossRefPubMed
17.
Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M: Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res. 2006, 66: 10269-10273. 10.1158/0008-5472.CAN-06-1500.CrossRefPubMed
18.
Fantin VR, St-Pierre J, Leder P: Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumour maintenance. Cancer Cell. 2006, 9: 425-434. 10.1016/j.ccr.2006.04.023.CrossRefPubMed
19.
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, et al: A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 2007, 11: 37-51. 10.1016/j.ccr.2006.10.020.CrossRefPubMed
20.
MacKenzie ED, Selak MA, Tennant DA, Payne LJ, Crosby S, Frederiksen CM, Watson DG, Gottlieb E: Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol Cell Biol. 2007, 27: 3282-3289. 10.1128/MCB.01927-06.CrossRefPubMedPubMedCentral
Metadata
Title
Metabolic approaches to breast cancer treatment and prevention
Author
Anthony Howell
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2007
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1825

Other articles of this Special Issue 2/2007

Breast Cancer Research 2/2007 Go to the issue

Short communication

Oxford Overview

Short communication

The case for user involvement in research: the research priorities of cancer patients

Short communication

Benefits of complementary therapies

Section introduction

Introduction to sessions on Personalising treatment

Short communication

Personalized surgical treatment of breast cancer

Short communication

Decision making in local therapy for breast cancer
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits