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Internal and Emergency Medicine
Published in: Internal and Emergency Medicine 1/2013

01-04-2013 | Review

Metabolic and cardiovascular effects of beta cell replacement in type 1 diabetes

Authors: Piero Marchetti, Margherita Occhipinti, Lorenzo Rondinini, Rita Mariotti, Gabriella Amorese, Massimiliano Barsotti, Fabio Vistoli, Ugo Boggi

Published in: Internal and Emergency Medicine | Special Issue 1/2013

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Abstract

Type 1 diabetes is associated with high morbidity and mortality, mostly due to the acute and chronic complications of the disease. Restoration of the lost beta cell mass by pancreas transplantation is the treatment of choice in selected type 1 diabetic patients. Growing data show that successful pancreas transplantation normalizes the metabolic alterations of diabetes, and can slow the progression, stabilize, and even favor the regression of secondary complications of the disease, including those at the cardiovascular level.
Literature
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American Diabetes Association (2013) Diagnosis and classification of diabetes mellitus. Diabetes Care 36:S67–S74CrossRef
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Di Cianni G, Benzi L, Giannarelli R, Orsini P, Villani G, Ciccarone AM, Cecchetti P, Fedele O, Navalesi R (1994) A prevalence study of known diabetes mellitus in Tuscany assessed from pharmaceutical prescriptions and other independent sources. Acta Diabetol 31:87–90PubMedCrossRef
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Boggi U, Vistoli F, Amorese G, Giannarelli R, Coppelli A, Mariotti R, Rondinini L, Barsotti M, Signori S, De Lio N, Occhipinti M, Mangione E, Cantarovich D, Del Prato S, Mosca F, Marchetti P (2012) Long-term (5 years) efficacy and safety of pancreas transplantation alone in type 1 diabetic patients. Transplantation 93:842–846PubMedCrossRef
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Gremizzi C, Vergani A, Paloschi V, Secchi A (2010) Impact of pancreas transplantation on type 1 diabetes-related complications. Curr Opin Organ Transplant 15:119–123PubMedCrossRef
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Boggi U, Rosati CM, Marchetti P (2013) Follow-up of secondary diabetic complications after pancreas transplantation. Curr Opin Organ Transplant 18:102–110PubMedCrossRef
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Occhipinti M, Rondinini L, Mariotti R, Scelza N, Barsotti M, Vistoli F, Amorese G, Boggi U, Marchetti P (2012) Cardiac morphology and function in type 1 diabetic patients with successful pancreas transplant alone. Diabetologia 55(suppl 1):S68
Metadata
Title
Metabolic and cardiovascular effects of beta cell replacement in type 1 diabetes
Authors
Piero Marchetti
Margherita Occhipinti
Lorenzo Rondinini
Rita Mariotti
Gabriella Amorese
Massimiliano Barsotti
Fabio Vistoli
Ugo Boggi
Publication date
01-04-2013
Publisher
Springer Milan
Published in
Internal and Emergency Medicine / Issue Special Issue 1/2013
Print ISSN: 1828-0447
Electronic ISSN: 1970-9366
DOI
https://doi.org/10.1007/s11739-013-0912-3

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