Published in:
01-07-2010 | Case Report
Mesenchymal stromal cells for steroid-refractory acute graft-versus-host disease: a report of two cases
Authors:
Joo Han Lim, Moon Hee Lee, Hyeon Gyu Yi, Chul Soo Kim, Jun Hyung Kim, Sun U. Song
Published in:
International Journal of Hematology
|
Issue 1/2010
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Abstract
Severe graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT). However, there have been only a few limited therapeutic options for the treatment of GVHD. Here we have reported two cases of the patients with acute steroid-refractory GVHD who underwent allogeneic HSCT. These patients received infusions of third-party clonal mesenchymal stem cells (cMSCs), which were isolated by a subfractionation culturing method (SCM) developed recently by our group, and showed marked improvement of the disease. MSCs represent a new potential therapeutic option in the treatment of steroid-refractory acute GVHD. They showed safety and improved clinical findings of the acute GVHD patients. However, further investigations are needed to understand the accurate mechanisms of MSCs and larger well-designed human clinical trials are necessary to prove further the safety and efficacy of the cMSCs for the treatment of acute GVHD patients.