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Transplantation Research
Published in: Transplantation Research 1/2012

Open Access 01-12-2012 | Review

Mesenchymal stem cell-educated macrophages

Authors: Elke Eggenhofer, Martin J Hoogduijn

Published in: Transplantation Research | Issue 1/2012

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Abstract

Mesenchymal stem cells (MSC) mediate their immunosuppressive effects via a variety of mechanisms. One of these mechanisms involves the induction of macrophages with immunomodulatory capacities. This effect of MSC may be exploited when MSC are used as a cell therapeutic product. Furthermore, MSC are resident in tissues where they may locally target infiltrating macrophages to adapt more regulatory properties. The present review discusses the interaction between MSC and macrophages, the induction of MSC-educated macrophages, how these cells position between other immune regulatory cells, and how they may be used in the clinic.
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Metadata
Title
Mesenchymal stem cell-educated macrophages
Authors
Elke Eggenhofer
Martin J Hoogduijn
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Transplantation Research / Issue 1/2012
Electronic ISSN: 2047-1440
DOI
https://doi.org/10.1186/2047-1440-1-12

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