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Journal of Ophthalmic Inflammation and Infection

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Open Access 01-12-2023 | Meropenem | Research

Successful treatment of multidrug-resistant Pseudomonas aeruginosa keratitis with meropenem eye drops — a case report

Authors: Carolin Elhardt, Armin Wolf, Christian Maximilian Wertheimer

Published in: Journal of Ophthalmic Inflammation and Infection | Issue 1/2023

Abstract

Background

This case report describes the course and therapeutic management of a fast-spreading bacterial keratitis caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa).

Case presentation

A 27-year-old male contact lens wearer presented with a multi-resistant, fast spreading P. aeruginosa keratitis. After initial resistance to various antibiotic therapies, testing revealed a MDR P. aeruginosa. The keratitis was treated successfully with specially prepared 50 mg/ml off-label meropenem eye drops for 18 days as well as systemic meropenem for seven days with rapid improvement of the corneal infiltrate.

Conclusion

This case report demonstrates the combination of topical and systemic meropenem as a useful treatment option for corneal ulcers caused by MDR P. aeruginosa.

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Title: Successful treatment of multidrug-resistant Pseudomonas aeruginosa keratitis with meropenem eye drops — a case report
Authors: Carolin Elhardt
Armin Wolf
Christian Maximilian Wertheimer
Publication date: 01-12-2023
Publisher: Springer Berlin Heidelberg
Keywords: Meropenem
Pseudomonas Aeruginosa
Antibiotic
Gentamicin
Moxifloxacin
Published in: Journal of Ophthalmic Inflammation and Infection / Issue 1/2023
Electronic ISSN: 1869-5760
DOI: https://doi.org/10.1186/s12348-023-00363-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Successful treatment of multidrug-resistant Pseudomonas aeruginosa keratitis with meropenem eye drops — a case report

Abstract

Background

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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