Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ASCO Annual Meeting 2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

2024 ASCO Annual Meeting

Keep up to date with all the top stories and latest evidence with our hub page, including official congress videos and expert takeaways.
ADVANCED SEARCH
Log in
Top
Journal of Infection and Chemotherapy
Published in: Journal of Infection and Chemotherapy 4/2011

Open Access 01-08-2011 | Case Report

Meningitis and septicemia caused by nontypeable Haemophilus influenzae in a previously healthy 2-year-old girl

Authors: Takao Ito, Hironori Shibata, Mie Nakazawa, Michiko Myokai, Kazuko Ikegaya, Ken Tsuchiya, Tsutomu Kamimaki

Published in: Journal of Infection and Chemotherapy | Issue 4/2011

Login to get access

Abstract

Nontypeable Haemophilus influenzae (NTHi) commonly colonizes the upper respiratory tract of children and causes otitis media, sinusitis, and bronchitis. Invasive NTHi diseases such as meningitis and septicemia have rarely been reported, especially in children with underlying predisposing conditions such as head trauma and immune compromise. However, we report a previously healthy 2-year-old girl who developed meningitis and septicemia caused by NTHi biotype ΙΙΙ. She was treated with dexamethasone, meropenem, and ceftriaxone, and recovered uneventfully. We wish to emphasize that NTHi should be borne in mind as a potential pathogen that can cause meningitis and septicemia, even in previously healthy children.
Literature
1.
Heath PT, Booy R, Azzopardi HJ, Slack MP, Fogarty J, Moloney AC, et al. Non-type b Haemophilus influenzae disease: clinical and epidemiologic characteristics in the Haemophilus influenzae type b vaccine era. Pediatr Infect Dis J. 2001;20:300–5.PubMedCrossRef
2.
Murphy TF, Faden H, Bakaletz LO, Kyd JM, Forsgren A, Campos J, et al. Nontypeable Haemophilus influenzae as a pathogen in children. Pediatr Infect Dis J. 2009;28:43–8.PubMedCrossRef
3.
O’Neill JM, St. Geme JW 3rd, Cutter D, Adderson EE, Anyanwu J, Jacobs RF, et al. Invasive disease due to nontypeable Haemophilus influenzae among children in Arkansas. J Clin Microbiol. 2003;41:3064–9.PubMedCrossRef
4.
Kunze W, Müller L, Kilian M, Schuhmann MU, Baumann L, Handrick W. Recurrent posttraumatic meningitis due to nontypeable Haemophilus influenzae: case report and review of the literature. Infection. 2008;36:74–7.PubMedCrossRef
5.
Martinello RA, Teitelbaum J, Young E, Hostetter MK. Nontypeable Haemophilus influenzae meningitis in an eleven-year-old. Pediatr Infect Dis J. 2004;23(281):285–6.
6.
Faden H. Meningitis caused by nontypeable Haemophilus influenzae in a four-month-old infant. Pediatr Infect Dis J. 1991;10:254–5.PubMedCrossRef
7.
Retter ME, Bannatyne RM. Neonatal infection with Haemophilus influenzae biotype ΙΙΙ. Can Med Assoc J. 1980;123:717–8.PubMed
8.
Hershckowitz S, Elisha MB, Fleisher-Sheffer V, Barak M, Kudinsky R, Weintraub Z. A cluster of early neonatal sepsis and pneumonia caused by nontypeable Haemophilus influenzae. Pediatr Infect Dis J. 2004;23:1061–2.PubMedCrossRef
9.
Kay SE, Nack Z, Jenner BM. Meningitis and septicemia in a child caused by non-typable Haemophilus influenzae biotype ΙΙΙ. Med J Aust. 2001;175:484–5.PubMed
10.
Cuthill SL, Farley MM, Donowitz LG. Nontypeable Haemophilus influenzae meningitis. Pediatr Infect Dis J. 1999;18:660–2.PubMedCrossRef
11.
Nizet V, Colina KF, Almquist JR, Rubens CE, Smith AL. A virulent nonencapsulated Haemophilus influenzae. J Infect Dis. 1996;173:180–6.PubMedCrossRef
12.
Kamiya H, Uehara S, Kato T, et al. Childhood bacterial meningitis in Japan. Pediatr Infect Dis J. 1998;17:S183–5.PubMedCrossRef
13.
Hasegawa K, Chiba N, Kobayashi R, et al. Nationwide Surveillance Study Group for Bacterial Meningitis. Molecular epidemiology of Haemophilus influenzae strains isolated from patients with meningitis during 1999 to 2003. Kansenshogaku Zasshi. 2004;78:835–45.PubMed
14.
Ishiwada N, Cao LD, Kohno Y. PCR-based capsular serotype determination of Haemophilus influenzae strains recovered from Japanese paediatric patients with invasive infection. Clin Microbiol Infect. 2004;10:895–8.PubMedCrossRef
15.
Pittman M. Variation and type specificity in bacterial species of Haemophilus influenzae. J Exp Med. 1931;53:471–92.PubMedCrossRef
16.
Kilian M. A taxonomic study of the genus Haemophilus with the proposal of a new species. J Gen Microbiol. 1976;93:9–62.PubMed
17.
Mazloum HA, Kilian M, Mohamed ZM, Said MD. Differentiation of Haemophilus aegyptius and Haemophilus influenzae. Acta Pathol Microbiol Immunol Scand B. 1982;90:109–12.PubMed
18.
Hoiseth SK, Connelly CJ, Moxon ER. Genetics of spontaneous, high-frequency loss of b capsule expression in Haemophilus influenzae. Infect Immun. 1985;49:389–95.PubMed
19.
Falla TJ, Dobson SR, Crook DW, et al. Population-based study of non-typable Haemophilus influenzae invasive disease in children and neonates. Lancet. 1993;341:851–4.PubMedCrossRef
Metadata
Title
Meningitis and septicemia caused by nontypeable Haemophilus influenzae in a previously healthy 2-year-old girl
Authors
Takao Ito
Hironori Shibata
Mie Nakazawa
Michiko Myokai
Kazuko Ikegaya
Ken Tsuchiya
Tsutomu Kamimaki
Publication date
01-08-2011
Publisher
Springer Japan
Published in
Journal of Infection and Chemotherapy / Issue 4/2011
Print ISSN: 1341-321X
Electronic ISSN: 1437-7780
DOI
https://doi.org/10.1007/s10156-011-0213-6

Other articles of this Issue 4/2011

Journal of Infection and Chemotherapy 4/2011 Go to the issue

Note

Two squalene synthase inhibitors, E5700 and ER-119884, interfere with cellular proliferation and induce ultrastructural and lipid profile alterations in a Candida tropicalis strain resistant to fluconazole, itraconazole, and amphotericin B

Note

The usefulness of changing focus during examination using Gram staining as initial diagnostic clue for infective tuberculosis

Original Article

Molecular typing and in-vitro activity of azoles against clinical isolates of Aspergillus fumigatus and A. niger in Japan

Original Article

Clinical viability of Fungitell, a new (1→3)-β-d-glucan measurement kit, for diagnosis of invasive fungal infection, and comparison with other kits available in Japan

Case Report

A case with fistula formation between a perinephric retroperitoneal abscess and the duodenum: successful outcome after conservative management

Case Report

The first case of bloodstream infection by Candida intermedia in Japan: the importance of molecular identification
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits