Published in:
01-07-2017 | Correspondence
Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature
Authors:
Felix Sahm, Umut H. Toprak, Daniel Hübschmann, Kortine Kleinheinz, Ivo Buchhalter, Martin Sill, Damian Stichel, Matthias Schick, Melanie Bewerunge-Hudler, Daniel Schrimpf, Gelareh Zadeh, Ken Aldape, Christel Herold-Mende, Katja Beck, Ori Staszewski, Marco Prinz, Carmit Ben Harosh, Roland Eils, Dominik Sturm, David T. W. Jones, Stefan M. Pfister, Werner Paulus, Zvi Ram, Matthias Schlesner, Rachel Grossman, Andreas von Deimling
Published in:
Acta Neuropathologica
|
Issue 1/2017
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Excerpt
Meningiomas not only occur sporadically or in the context of neurofibromatosis type 2, but can also be induced by radiation [
7]. High-dose radiation-induced meningiomas (Mrad) predominantly arise after radiation for other brain tumors (often in childhood) with doses of 40–60 Gy. Most low-dose Mrad have been detected in patients receiving 3–4 Gy to the scalp for tinea capitis [
6,
9]. Analysis of these tumors is paradigmatic for radiation-induced tumorigenesis, particularly in the absence of a prior tumor and chemotherapy and a model for collateral exposure surrounding the target of high-dose irradiation. So far, little molecular overlap between Mrad and sporadic meningiomas has been detected [
6,
9]. …
