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Journal of Neuro-Oncology

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01-07-2020 | Meningioma | Clinical Study

Management of incidental anterior skull base large and giant meningiomas in elderly patients

Authors: Yuqian Li, Dan Lu, Dayun Feng, Hongyu Cheng, Qian Huang, Haikang Zhao, Peng Chen, Huaizhou Qin, Qing Cai

Published in: Journal of Neuro-Oncology | Issue 3/2020

Abstract

Introduction

The incidence of meningiomas among the elderly is considered to be high, and are at increased risk of severe morbidity and mortality following surgery due to their aging physiology and unexpected comorbidities. This study aimed to evaluate the optimal management strategies of meningiomas in elderly patients.

Methods

We retrospectively analyzed 150 patients with incidental large (≥ 3 cm) and giant (≥ 6 cm) anterior skull base meningiomas from 2009 to 2018. These patients were divided into elderly group (≥ 65 years, n = 70) and younger group (< 65 years, n = 80). Information of patients with regard to their medical records, operative details, relevant imaging, and follow-up data were obtained from their respective electronic medical records.

Results

The elderly patients had significantly longer length of hospital stay (15.9 ± 3.5) compared to younger patients (13.6 ± 3.6, P < 0.001). Karnofsky Performance Scale (KPS) at discharge was significantly lower in elderly group when compared to younger group (P = 0.04). However, the KPS at 1-year after surgery was similar between the two groups. In addition, there was no significant difference in the incidence of surgical complications between the two groups. Multivariate regression analysis of postoperative complications revealed blood loss ≥ 800 mL (P = 0.007) and BMI (< 18.5 or ≥ 24, P < 0.001) as risk factors, rather than age.

Conclusions

Surgical resection in elderly patients with incidental anterior skull base large and giant meningiomas is considered to be a safe and effective therapeutic option owing to acceptable mortality, postoperative complications and postoperative clinical outcomes.

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Title: Management of incidental anterior skull base large and giant meningiomas in elderly patients
Authors: Yuqian Li
Dan Lu
Dayun Feng
Hongyu Cheng
Qian Huang
Haikang Zhao
Peng Chen
Huaizhou Qin
Qing Cai
Publication date: 01-07-2020
Publisher: Springer US
Keywords: Meningioma
Meningioma
Published in: Journal of Neuro-Oncology / Issue 3/2020
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-020-03484-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Management of incidental anterior skull base large and giant meningiomas in elderly patients

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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