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Open Access 25-08-2023 | Meningioma | Review

Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology

Authors: Hanya M. Qureshi, Joanna K. Tabor, Kiley Pickens, Haoyi Lei, Sagar Vasandani, Muhammad I. Jalal, Shaurey Vetsa, Aladine Elsamadicy, Neelan Marianayagam, Brianna C. Theriault, Robert K. Fulbright, Ruihan Qin, Jiarui Yan, Lan Jin, Joseph O’Brien, Saul F. Morales-Valero, Jennifer Moliterno

Published in: Journal of Neuro-Oncology | Issue 2/2023

Abstract

Purpose

Frailty has gained prominence in neurosurgical oncology, with more studies exploring its relationship to postoperative outcomes in brain tumor patients. As this body of literature continues to grow, concisely reviewing recent developments in the field is necessary. Here we provide a systematic review of frailty in brain tumor patients subdivided by tumor type, incorporating both modern frailty indices and traditional Karnofsky Performance Status (KPS) metrics.

Methods

Systematic literature review was performed using PRISMA guidelines. PubMed and Google Scholar were queried for articles related to frailty, KPS, and brain tumor outcomes. Only articles describing novel associations between frailty or KPS and primary intracranial tumors were included.

Results

After exclusion criteria, systematic review yielded 52 publications. Amongst malignant lesions, 16 studies focused on glioblastoma. Amongst benign tumors, 13 focused on meningiomas, and 6 focused on vestibular schwannomas. Seventeen studies grouped all brain tumor patients together. Seven studies incorporated both frailty indices and KPS into their analyses. Studies correlated frailty with various postoperative outcomes, including complications and mortality.

Conclusion

Our review identified several patterns of overall postsurgical outcomes reporting for patients with brain tumors and frailty. To date, reviews of frailty in patients with brain tumors have been largely limited to certain frailty indices, analyzing all patients together regardless of lesion etiology. Although this technique is beneficial in providing a general overview of frailty’s use for brain tumor patients, given each tumor pathology has its own unique etiology, this combined approach potentially neglects key nuances governing frailty’s use and prognostic value.

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Title: Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology
Authors: Hanya M. Qureshi
Joanna K. Tabor
Kiley Pickens
Haoyi Lei
Sagar Vasandani
Muhammad I. Jalal
Shaurey Vetsa
Aladine Elsamadicy
Neelan Marianayagam
Brianna C. Theriault
Robert K. Fulbright
Ruihan Qin
Jiarui Yan
Lan Jin
Joseph O’Brien
Saul F. Morales-Valero
Jennifer Moliterno
Publication date: 25-08-2023
Publisher: Springer US
Keywords: Meningioma
Meningioma
Brain Tumor
Vestibular Schwannoma
Vestibular Schwannoma
Glioblastoma
Glioblastoma
Glioblastoma
Published in: Journal of Neuro-Oncology / Issue 2/2023
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-023-04416-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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