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Open Access 01-12-2020 | Meningioma | Research article

Predictors of pre-operative cognitive impairment in meningioma patients over 60 years old

Authors: Min Ju Kang, Jung-Min Pyun, Min Jae Baek, Kihwan Hwang, Jung Ho Han, Young Ho Park, Chae-Yong Kim, SangYun Kim

Published in: BMC Neurology | Issue 1/2020

Abstract

Background

The aim of this study was to assess the cognitive function of patients over 60 years old with meningioma using a domain-specific neuropsychological test and to investigate the relevant factors affecting pre-operative cognitive decline in different subdomains.

Methods

We retrospectively investigated 46 intracranial meningioma patients between the ages of 60 and 85 years. All patients underwent brain MRI and neuropsychological test. Tumor size, location, peritumoral edema, and medial temporal atrophy (MTA) were examined to determine the association with cognitive impairment. We performed a logistic regression analysis to examine the odds ratios (ORs) for cognitive decline of four subdomains: verbal memory, language, visuospatial, and executive functions.

Results

Tumor size and age were associated with executive dysfunction (OR 1.083, 95% confidence interval (CI) 1.006–1.166, and OR 1.209, 95% CI 1.018–1.436, respectively). There was no statistically significant association in other cognitive domains (language, verbal memory, and visuospatial function) with variables in regression analysis.

Conclusions

We conclude that tumor size and age are positively related with executive function in pre-operative meningioma patients over 60 years old.

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Title: Predictors of pre-operative cognitive impairment in meningioma patients over 60 years old
Authors: Min Ju Kang
Jung-Min Pyun
Min Jae Baek
Kihwan Hwang
Jung Ho Han
Young Ho Park
Chae-Yong Kim
SangYun Kim
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Meningioma
Edema
Meningioma
Published in: BMC Neurology / Issue 1/2020
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-020-01806-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Predictors of pre-operative cognitive impairment in meningioma patients over 60 years old

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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