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Digestive Diseases and Sciences

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01-11-2012 | Original Article

Menarche in Pediatric Patients with Crohn’s Disease

Authors: Neera Gupta, Robert H. Lustig, Michael A. Kohn, Eric Vittinghoff

Published in: Digestive Diseases and Sciences | Issue 11/2012

Abstract

Background and Aims

The timing of menarche in Crohn’s disease (CD) is poorly described. Our objectives were to study age at menarche onset in CD, and factors associated with this.

Methods

We compared the age at menarche of 34 CD patients with that for 545 controls, using data in the National Health and Nutrition Examination Survey (NHANES).

Results

Mean chronological age (CA) of CD patients (15.6 years) did not differ from that of the NHANES cohort (15.7 years; P = 0.91). The median CA at menarche (13.9 years) in CD was older than in the NHANES sample (12.0 years) (P < 0.00005). In CD patients, the cumulative incidence of menarche was 10 % at CA 12 years, 51 % at CA 14 years, and 100 % at CA 16 years. Sixty-eight percent reached menarche by bone age (BA) 13.5 years and 100 % by BA greater than 14.0 years. Menarche occurred earliest in South Asians, followed by East Asians, and then Caucasians (P = 0.02).

Conclusions

CA at menarche is delayed in CD compared with the NHANES cohort. BA at menarche in CD is similar to BA at menarche reported for healthy children. CA at menarche in CD differs by race. If menarche has not occurred by BA greater than 14.0 years, endocrinology referral should be considered.

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Title: Menarche in Pediatric Patients with Crohn’s Disease
Authors: Neera Gupta
Robert H. Lustig
Michael A. Kohn
Eric Vittinghoff
Publication date: 01-11-2012
Publisher: Springer US
Published in: Digestive Diseases and Sciences / Issue 11/2012
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-012-2235-z

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Abstract

Background and Aims

Methods

Results

Conclusions

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