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01-07-2009 | Brief Report

Membranoproliferative glomerulonephritis associated with a mutation in Wilms’ tumour suppressor gene 1

Authors: Detlef Bockenhauer, William van’t Hoff, Gil Chernin, Saskia F. Heeringa, Neil J. Sebire

Published in: Pediatric Nephrology | Issue 7/2009

Abstract

Wilms’ tumour suppressor gene 1 (WT1) encodes a transcription factor required for normal development of the genitourinary system. In the kidney, mutations in WT1 can cause diffuse mesangial sclerosis or focal segmental glomerulosclerosis. Here, we report on a girl with a mutation in WT1, who developed membranoproliferative glomerulonephritis (MPGN) 3 years after completion of treatment for Wilms’ tumour. This finding extends the spectrum of glomerular disease seen with WT1 mutations and could have implications for the screening of children with MPGN.

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Title: Membranoproliferative glomerulonephritis associated with a mutation in Wilms’ tumour suppressor gene 1
Authors: Detlef Bockenhauer
William van’t Hoff
Gil Chernin
Saskia F. Heeringa
Neil J. Sebire
Publication date: 01-07-2009
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 7/2009
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-009-1135-8

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Membranoproliferative glomerulonephritis associated with a mutation in Wilms’ tumour suppressor gene 1

Abstract

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Abstract

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