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BMC Complementary Medicine and Therapies

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Open Access 01-12-2021 | Melanoma | Research

Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers

Authors: Hiva Alipanah, Mojtaba Farjam, Elham Zarenezhad, Ghazaal Roozitalab, Mahmoud Osanloo

Published in: BMC Complementary Medicine and Therapies | Issue 1/2021

Abstract

Background

Melanoma and breast cancers are two common cancers worldwide. Due to the side effects of chemotherapy drugs and the occurring resistance against them, the development of green drugs has been received more attention.

Methods

The anticancer effects of three essential oils from the Citrus family and their identified major constituents (limonene) were first investigated against melanoma and breast cancer cell lines (A-375 and MDA-MB-468). By preparing chitosan nanoparticles containing them, an attempt was then made to improve their effectiveness.

Results

Chitosan nanoparticles containing Citrus sinensis and Citrus limon essential oils with IC₅₀s of 0.03 and 0.124 μg/mL on A-375 cells, and 23.65 and 40.32 μg/mL on MDA-MB-468 showed distinct anticancer efficacies.

Conclusion

The prepared formulations could thus be considered as green anticancer agents in complementary medicine and therapies.

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Title: Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers
Authors: Hiva Alipanah
Mojtaba Farjam
Elham Zarenezhad
Ghazaal Roozitalab
Mahmoud Osanloo
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Melanoma
Melanoma
Breast Cancer
Breast Cancer
Published in: BMC Complementary Medicine and Therapies / Issue 1/2021
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/s12906-021-03362-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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