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01-10-2012 | Original article

Medulloblastoma in adults

Treatment outcome, relapse patterns, and prognostic factors

Authors: S.-F. Lai, M.D., C.-W. Wang, M.D., Ph.D., Y.-H. Chen, M.D., K.-H. Lan, M.D., Ph.D., J.C.-H. Cheng, M.D., Ph.D., A.-L. Cheng, M.D., Ph.D., S.-H. Kuo, M.D., Ph.D.

Published in: Strahlentherapie und Onkologie | Issue 10/2012

Abstract

Background and purpose

In this study, the clinical outcome and prognostic factors of adult medulloblastoma patients receiving multimodal treatment were investigated.

Patients and methods

The clinical manifestations, treatment variables, and outcome of adult patients with medulloblastoma at our institution between 1983 and 2009 were retrospectively reviewed.

Results

A total of 20 adult patients were included (median age 22 years). Craniospinal irradiation (CSI) was given postoperatively. The craniospinal axis received a median of 30 Gy (range 23.4–39.6 Gy) in fractions of 1.6–2 Gy/day, and the tumor was boosted to a total median dose of 50 Gy (range 50–55.25 Gy). The 3-year disease-free survival (DFS) and overall survival (OS) rates for all patients were 45% and 50%, respectively. In univariate analysis, Karnofsky Performance Scale (KPS) > 70, neurologic symptoms duration > 30 days, lateral tumor location, standard risk patients, no hydrocephalus, radiotherapy (RT) treatment field (CSI + brain boost), and CSI dose ≥ 30 Gy were associated with better DFS. Standard-risk patients, RT treatment field (CSI + brain boost), and CSI dose ≥ 30 Gy were also significantly associated with better OS.

Conclusion

The combined modality treatment results in a favorable outcome for adult medulloblastoma patients. Further investigation of the prognostic factors, radiation-related factors, and systemic chemotherapy is needed.

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Title: Medulloblastoma in adults
Treatment outcome, relapse patterns, and prognostic factors
Authors: S.-F. Lai, M.D.
C.-W. Wang, M.D., Ph.D.
Y.-H. Chen, M.D.
K.-H. Lan, M.D., Ph.D.
J.C.-H. Cheng, M.D., Ph.D.
A.-L. Cheng, M.D., Ph.D.
S.-H. Kuo, M.D., Ph.D.
Publication date: 01-10-2012
Publisher: Springer-Verlag
Published in: Strahlentherapie und Onkologie / Issue 10/2012
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-012-0168-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Medulloblastoma in adults

Treatment outcome, relapse patterns, and prognostic factors

Abstract

Background and purpose

Patients and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background and purpose

Patients and methods

Results

Conclusion

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