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Clinical Oral Investigations

Published in:

01-01-2013 | Original Article

Mechanical stress induces bone formation in the maxillary sinus in a short-term mouse model

Authors: Shingo Kuroda, Rima Wazen, Pierre Moffatt, Eiji Tanaka, Antonio Nanci

Published in: Clinical Oral Investigations | Issue 1/2013

Abstract

Objectives

Clinicians occasionally face the challenge of moving a tooth through the maxillary sinus. The objective of this study was to evaluate tissue remodeling during tooth movement into the maxillary sinus, more specifically as regards to bone formation.

Materials and methods

The maxillary first molar of 20 male mice was moved toward the palatal side by a nickel–titanium super elastic wire for 1 to 14 days, and the bone remodeling around the root was evaluated using histomorphometry and immunodetection of bone-restricted Ifitm-like (Bril) protein, a novel marker of active bone formation.

Results

When mechanical stress was applied to the tooth, the periodontal ligament on the palatal side was immediately compressed to approximately half of its original width by the tipping movement of the tooth. At the same time, osteoblasts deposited new bone on the wall of the maxillary sinus prior to bone resorption by osteoclasts on the periodontal side, as evidenced by the high level of expression of Bril at this site. As a result of these sequential processes, bone on the sinus side maintained a consistent thickness during the entire observation period. No root resorption was observed.

Conclusions

Bone formation on the surface of the maxillary sinus was evoked by mechanotransduction of mechanical stress applied to a tooth over a 2-week period, and was induced ahead of bone resorption on the periodontal ligament side.

Clinical relevance

Mechanical stress can be exploited to induce bone formation in the maxillary sinus so that teeth can be moved into the sinus without losing bone or causing root damage.

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Title: Mechanical stress induces bone formation in the maxillary sinus in a short-term mouse model
Authors: Shingo Kuroda
Rima Wazen
Pierre Moffatt
Eiji Tanaka
Antonio Nanci
Publication date: 01-01-2013
Publisher: Springer-Verlag
Published in: Clinical Oral Investigations / Issue 1/2013
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-012-0686-4

At a glance: The STEP trials

Springer Medicine

Mechanical stress induces bone formation in the maxillary sinus in a short-term mouse model

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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