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Quality of Life Research
Published in: Quality of Life Research 9/2009

Open Access 01-11-2009

Measuring health-related quality of life in population-based studies of coronary heart disease: comparing six generic indexes and a disease-specific proxy score

Authors: Noelle C. Garster, Mari Palta, Nancy K. Sweitzer, Robert M. Kaplan, Dennis G. Fryback

Published in: Quality of Life Research | Issue 9/2009

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Abstract

Purpose

To compare HRQoL differences with CHD in generic indexes and a proxy CVD-specific score in a nationally representative sample of U.S. adults.

Methods

The National Health Measurement Study, a cross-sectional random-digit-dialed telephone survey of adults aged 35–89, administered the EQ-5D, QWB-SA, HUI2, HUI3, SF-36v2™ (yielding PCS, MCS, and SF-6D), and HALex. Analyses compared 3,350 without CHD (group 1), 265 with CHD not taking chest pain medication (group 2), and 218 with CHD currently taking chest pain medication (group 3), with and without adjustment for demographic variables and comorbidities. Data on 154 patients from heart failure clinics were used to construct a proxy score utilizing generic items probing CVD symptoms.

Results

Mean scores differed between CHD groups for all indexes with and without adjustment (P < 0.0001 for all except MCS P = 0.018). Unadjusted group 3 versus 1 differences were about three times larger than for group 2 versus 1. Standardized differences for the proxy score were similar to those for generic indexes, and were about 1.0 for all except MCS for group 3 versus 1.

Conclusions

Generic indexes capture differences in HRQoL in population-based studies of CHD similarly to a score constructed from questions probing CVD-specific symptoms.
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Metadata
Title
Measuring health-related quality of life in population-based studies of coronary heart disease: comparing six generic indexes and a disease-specific proxy score
Authors
Noelle C. Garster
Mari Palta
Nancy K. Sweitzer
Robert M. Kaplan
Dennis G. Fryback
Publication date
01-11-2009
Publisher
Springer Netherlands
Published in
Quality of Life Research / Issue 9/2009
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-009-9533-8

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