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Annals of Nuclear Medicine

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01-06-2009 | Original Article

Measurement of cerebral blood flow by the autoradiographic method with N-isopropyl-4-[I-123] iodoamphetamine: comparison of radiopharmaceuticals marketed by different companies in Japan

Authors: Toshiyuki Ogura, Hiroshi Ito, Kazuhiro Hida, Toshihide Masuzuka, Hiroshi Fukuda, Jun Hatazawa

Published in: Annals of Nuclear Medicine | Issue 4/2009

Abstract

Objective

Iodine-123-labeled N-isopropyl-4-iodoamphetamine (IMP) is used as a tracer for the measurement of cerebral blood flow (CBF) by single-photon emission computed tomography (SPECT). Two IMP products, IMP_A (Nihon Medi-Physics Co., Ltd.) and IMP_B (FUJIFILM RI Pharma Co., Ltd.), produced by different radiopharmaceutical companies are marketed for clinical use in Japan. Although no significant difference in whole-body distribution between the two products has been reported, a significant difference in the radioactivity of the octanol-extracted fraction in whole blood between the two products has been reported in humans. In this study, CBF values obtained by the autoradiographic (ARG) method obtained from both IMP_A and IMP_B were compared in the same human subjects.

Methods

SPECT studies were performed on 6 healthy subjects with the use of both IMP_A and IMP_B. Standard input functions used in the ARG method were obtained for both IMP_A and IMP_B from 5 additional healthy subjects.

Results

Significant differences were found between CBF values when SPECT data with IMP_A was combined with the standard input function for IMP_B (37.7 ± 3.7 mL/100 g/min at a mid-scan time of 30 min) and SPECT data with IMP_B was combined with the standard input function for IMP_A (50.7 ± 8.9 mL/100 g/min). Nearly the same CBF values were found when SPECT data with IMP_A was combined with the standard input function for IMP_A (43.1 ± 4.4 mL/100 g/min) and SPECT data with IMP_B was combined with the standard input function for IMP_B (44.2 ± 7.6 mL/100 g/min).

Conclusions

Our results suggest that the appropriate standard input function should be used, according to the IMP product used, in the calculation of CBF by the ARG method.

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Title: Measurement of cerebral blood flow by the autoradiographic method with N-isopropyl-4-[I-123] iodoamphetamine: comparison of radiopharmaceuticals marketed by different companies in Japan
Authors: Toshiyuki Ogura
Hiroshi Ito
Kazuhiro Hida
Toshihide Masuzuka
Hiroshi Fukuda
Jun Hatazawa
Publication date: 01-06-2009
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 4/2009
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-009-0242-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Measurement of cerebral blood flow by the autoradiographic method with N-isopropyl-4-[I-123] iodoamphetamine: comparison of radiopharmaceuticals marketed by different companies in Japan

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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