A 3-year-and-5-month-old girl was referred for evaluation of vaginal bleeding lasting 8 days. The results of a physical examination were unremarkable. Pelvic ultrasound showed uterine enlargement and left ovarian cyst measuring 1.6 × 2.5 cm (A, arrow). Serum sex hormones and insulin-like growth factor 1 were normal except for an elevated estradiol concentration (222 pmol/L). Biochemical testing revealed normal thyroid function tests but elevated alkaline phosphatase of 226 U/L (N, 40–150). Her X-rays of the limbs were all normal. Bone scintigraphy with 99mTc-MDP was performed and demonstrated two intense activities in the skull (B), which were both shown as ground glass appearances located in the occipital by SPECT / CT (C and D, arrows, coronal position), favoring the diagnosis of fibrous dysplasia (FD). Due to the presence of precocious puberty and FD, the patient was subsequently diagnosed with McCune-Albright syndrome (MAS).