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Published in: Pediatric Nephrology 1/2006

01-01-2006 | Editorial Commentary

May we go on with antibacterial prophylaxis for urinary tract infections?

Author: R. Beetz

Published in: Pediatric Nephrology | Issue 1/2006

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Abstract

Recurrent urinary tract infections (UTIs), with or without vesicoureteric reflux (VUR), are by far the most frequent reason for long-term antibacterial prophylaxis in infants and children today. However, the strategies of antibacterial prophylaxis for the prevention of recurrent urinary tract infection are no longer universally accepted. In infants and children at risk, the benefits of antibacterial prophylaxis definitively are not yet proven by evident data. To put antibacterial prophylaxis in its place, risk groups for recurrent symptomatic infections, ascending UTI and permanent renal damage have to be defined and the efficacy of prophylaxis in these groups has to be proved by prospective randomised studies. Nevertheless, until the results of these studies are available, antibacterial prophylaxis will remain one of the most frequently practised methods to protect risk patients from pyelonephritic damage and UTI recurrences.
Literature
2.
3.
go back to reference Marshall M Jr, Johnson SH (1956) An initial report of the treatment of chronic urinary tract infection in children with nitrofurantoin. J Urol 76:123–128PubMed Marshall M Jr, Johnson SH (1956) An initial report of the treatment of chronic urinary tract infection in children with nitrofurantoin. J Urol 76:123–128PubMed
4.
go back to reference Stansfield JM, Webb JGG (1954) A plea for the longer treatment of chronic pyelonephritis in children. BMJ 1:616–618CrossRef Stansfield JM, Webb JGG (1954) A plea for the longer treatment of chronic pyelonephritis in children. BMJ 1:616–618CrossRef
5.
go back to reference Smellie JM, Hodson CJ, Edwards D, Normand ICS (1964) Clinical and radiological features of urinary tract infection in childhood. Br Med J 2:1222–1226PubMedCentralPubMedCrossRef Smellie JM, Hodson CJ, Edwards D, Normand ICS (1964) Clinical and radiological features of urinary tract infection in childhood. Br Med J 2:1222–1226PubMedCentralPubMedCrossRef
6.
go back to reference Smellie JM, Grüneberg RN, Leakey A, Atkin WS (1976) Long-term low-dose co-trimoxazole in prophylaxis of childhood urinary tract infection: clinical aspects. Br Med J 2:203–206PubMedCentralPubMedCrossRef Smellie JM, Grüneberg RN, Leakey A, Atkin WS (1976) Long-term low-dose co-trimoxazole in prophylaxis of childhood urinary tract infection: clinical aspects. Br Med J 2:203–206PubMedCentralPubMedCrossRef
7.
go back to reference Smellie JM, Katz G, Grueneberg RN (1978) Controlled trial of prophylactic treatment in childhood urinary tract infection. Lancet ii:175–178CrossRef Smellie JM, Katz G, Grueneberg RN (1978) Controlled trial of prophylactic treatment in childhood urinary tract infection. Lancet ii:175–178CrossRef
8.
go back to reference Lohr JA, Nunley DH, Howards SS, Ford RF (1977) Prevention of recurrent urinary tract infections in girls. Pediatrics 59:562–565PubMed Lohr JA, Nunley DH, Howards SS, Ford RF (1977) Prevention of recurrent urinary tract infections in girls. Pediatrics 59:562–565PubMed
9.
go back to reference Smellie JM, Grüneberg RN, Normand ICS, Bantock HM (1982) Trimethoprim-sulfamethoxazole and trimethoprim alone in the prophylaxis of childhood urinary tract infection. Rev Infect Dis 4:461–466PubMedCrossRef Smellie JM, Grüneberg RN, Normand ICS, Bantock HM (1982) Trimethoprim-sulfamethoxazole and trimethoprim alone in the prophylaxis of childhood urinary tract infection. Rev Infect Dis 4:461–466PubMedCrossRef
10.
go back to reference Williams G, Lee A, Craig JC (2001) Antibiotics for the prevention of urinary tract infection in children: a systematic review of randomised controlled trials. J Pediatr 138:868–874PubMedCrossRef Williams G, Lee A, Craig JC (2001) Antibiotics for the prevention of urinary tract infection in children: a systematic review of randomised controlled trials. J Pediatr 138:868–874PubMedCrossRef
11.
go back to reference Jodal U, Winberg J (1987) Management of children with unobstructed urinary tract infection. Pediatr Nephrol 1:647–656PubMedCrossRef Jodal U, Winberg J (1987) Management of children with unobstructed urinary tract infection. Pediatr Nephrol 1:647–656PubMedCrossRef
12.
go back to reference Elder JS, Peters CA, Arant BS, Ewalt DH, Hawtrey CE, Hurwitz RS, Parrott TS, Snyder HM, Weis RA, Woolf SH, Hasselblad V (1997) Pediatric vesicoureteral reflux guidelines panel summary report on the management of primary vesicoureteral reflux in children. J Urol 157:1846–1851PubMedCrossRef Elder JS, Peters CA, Arant BS, Ewalt DH, Hawtrey CE, Hurwitz RS, Parrott TS, Snyder HM, Weis RA, Woolf SH, Hasselblad V (1997) Pediatric vesicoureteral reflux guidelines panel summary report on the management of primary vesicoureteral reflux in children. J Urol 157:1846–1851PubMedCrossRef
13.
go back to reference Lindert KA, Shortliffe LMD (1999) Evaluation and management of pediatric urinary tract infections. Urol Clin North Am 26:719–728PubMedCrossRef Lindert KA, Shortliffe LMD (1999) Evaluation and management of pediatric urinary tract infections. Urol Clin North Am 26:719–728PubMedCrossRef
14.
15.
go back to reference Fine RN (1992) Diagnosis and treatment of fetal urinary tract abnormalities. J Pediatr 121:333–341PubMedCrossRef Fine RN (1992) Diagnosis and treatment of fetal urinary tract abnormalities. J Pediatr 121:333–341PubMedCrossRef
16.
go back to reference Winberg J, Bollgren I, Källenius G, Möllby R, Svenson SB (1982) Clinical pyelonephritis and focal renal scarring. A selected review of pathogenesis, prevention, and prognosis. Pediatr Clin North Am 29:801–814PubMed Winberg J, Bollgren I, Källenius G, Möllby R, Svenson SB (1982) Clinical pyelonephritis and focal renal scarring. A selected review of pathogenesis, prevention, and prognosis. Pediatr Clin North Am 29:801–814PubMed
17.
go back to reference Winberg J, Bergstrom T, Jacobsson B (1975) Mortality, age and sex distribution, recurrences and renal scarring in symptomatic urinary tract infection in childhood. Kidney Int [Suppl] S101–S106 Winberg J, Bergstrom T, Jacobsson B (1975) Mortality, age and sex distribution, recurrences and renal scarring in symptomatic urinary tract infection in childhood. Kidney Int [Suppl] S101–S106
18.
go back to reference Nuutinen M, Uhari M (2001) Recurrence and follow-up after urinary tract infection under the age of 1 year. Pediatr Nephrol 16:69–72PubMedCrossRef Nuutinen M, Uhari M (2001) Recurrence and follow-up after urinary tract infection under the age of 1 year. Pediatr Nephrol 16:69–72PubMedCrossRef
19.
go back to reference McCracken GH (1984) Recurrent urinary tract infections in children. Pediatr Infect Dis 3:28–30CrossRef McCracken GH (1984) Recurrent urinary tract infections in children. Pediatr Infect Dis 3:28–30CrossRef
20.
go back to reference Kasanen A, Sundquist H, Elo J, Anttila M, Kangas L (1983) Secondary prevention of urinary tract infections. Ann Clin Res 15 [Suppl 36]: 5–36 Kasanen A, Sundquist H, Elo J, Anttila M, Kangas L (1983) Secondary prevention of urinary tract infections. Ann Clin Res 15 [Suppl 36]: 5–36
21.
go back to reference Kunin CM (1987) Detection, prevention and management of urinary tract infections. Lea & Febiger, Philadelphia Kunin CM (1987) Detection, prevention and management of urinary tract infections. Lea & Febiger, Philadelphia
22.
go back to reference Mannhardt W, Becker A, Putzer M, Bork M, Zepp F, Hacker J, Schulte-Wissermann H (1996) Host defense within the urinary tract. I. Bacterial adhesion initiates an uroepithelial defense mechanism. Pediatr Nephrol 10:568–572PubMedCrossRef Mannhardt W, Becker A, Putzer M, Bork M, Zepp F, Hacker J, Schulte-Wissermann H (1996) Host defense within the urinary tract. I. Bacterial adhesion initiates an uroepithelial defense mechanism. Pediatr Nephrol 10:568–572PubMedCrossRef
23.
go back to reference Hellerstein S, Nickell E (2002) Prophylactic antibiotics in children at risk for urinary tract infection. Pediatr Nephrol 17:506–510PubMedCrossRef Hellerstein S, Nickell E (2002) Prophylactic antibiotics in children at risk for urinary tract infection. Pediatr Nephrol 17:506–510PubMedCrossRef
24.
go back to reference Smellie JM, Grüneberg RN, Bantock HM, Prescod N (1988) Prophylactic co-trimoxazole and trimethoprim in the management of urinary tract infection in children. Pediatr Nephrol 2:12–17PubMedCrossRef Smellie JM, Grüneberg RN, Bantock HM, Prescod N (1988) Prophylactic co-trimoxazole and trimethoprim in the management of urinary tract infection in children. Pediatr Nephrol 2:12–17PubMedCrossRef
25.
go back to reference Jakobsson B, Nolstedt L, Svensson L, Söderlundh S, Berg U (1992) 99mTc-dimercaptosuccinic acid (DMSA) scan in the diagnosis of acute pyelonephritis in children: relation to clinical and radiological findings. Pediatr Nephrol 6:328–334PubMedCrossRef Jakobsson B, Nolstedt L, Svensson L, Söderlundh S, Berg U (1992) 99mTc-dimercaptosuccinic acid (DMSA) scan in the diagnosis of acute pyelonephritis in children: relation to clinical and radiological findings. Pediatr Nephrol 6:328–334PubMedCrossRef
26.
go back to reference Rushton HG, Majd M, Jantausch B, Wiedermann BL, Belman AB (1992) Renal scarring following reflux and nonreflux pyelonephritis in children: evaluation with 99mtechnetium-dimercaptosuccinic acid scintigraphy. J Urol 147:1327–1332PubMed Rushton HG, Majd M, Jantausch B, Wiedermann BL, Belman AB (1992) Renal scarring following reflux and nonreflux pyelonephritis in children: evaluation with 99mtechnetium-dimercaptosuccinic acid scintigraphy. J Urol 147:1327–1332PubMed
27.
go back to reference Jodal U (1987) The natural history of bacteriuria in childhood. Infect Dis Clin North Am 1:713–729PubMed Jodal U (1987) The natural history of bacteriuria in childhood. Infect Dis Clin North Am 1:713–729PubMed
28.
go back to reference Berg UB (1989) Renal dysfunction in recurrent urinary tract infections in childhood. Pediatr Nephrol 3:9–15PubMedCrossRef Berg UB (1989) Renal dysfunction in recurrent urinary tract infections in childhood. Pediatr Nephrol 3:9–15PubMedCrossRef
29.
30.
go back to reference Benador D, Benador N, Slozman D, Memillod B, Girardin E (1997) Are younger patients at higher risk of renal sequela after pyelonephritis? Lancet 349:17–19PubMedCrossRef Benador D, Benador N, Slozman D, Memillod B, Girardin E (1997) Are younger patients at higher risk of renal sequela after pyelonephritis? Lancet 349:17–19PubMedCrossRef
31.
go back to reference Ransley PG, Risdon RA (1978) Reflux and renal scarring. Br J Radiol [Suppl] 14:1–35 Ransley PG, Risdon RA (1978) Reflux and renal scarring. Br J Radiol [Suppl] 14:1–35
32.
33.
go back to reference Garin EH, Campos A, Homsy Y (1998) Primary vesicoureteral reflux: review of current concepts. Pediatr Nephrol 12:249–256PubMedCrossRef Garin EH, Campos A, Homsy Y (1998) Primary vesicoureteral reflux: review of current concepts. Pediatr Nephrol 12:249–256PubMedCrossRef
34.
go back to reference Wennerström M, Hansson S, Jodal U, Stokland E (2000) Primary and acquired renal scarring in boys and girls with urinary tract infection. J Pediatr 136:30–34CrossRef Wennerström M, Hansson S, Jodal U, Stokland E (2000) Primary and acquired renal scarring in boys and girls with urinary tract infection. J Pediatr 136:30–34CrossRef
35.
go back to reference Rushton HG (1997) The evaluation of acute pyelonephritis and renal scarring with technetium 99m-dimercaptosuccinic acid renal scintigraphy: evolving concepts and future directions. Pediatr Nephrol 11:108PubMedCrossRef Rushton HG (1997) The evaluation of acute pyelonephritis and renal scarring with technetium 99m-dimercaptosuccinic acid renal scintigraphy: evolving concepts and future directions. Pediatr Nephrol 11:108PubMedCrossRef
36.
go back to reference Wheeler D, Vimalachandra D, Hodson EM, Roy KLP, Smith G, Craig JC (2003) Antibiotics and surgery for VUR: a meta-analysis of randomised controlled trials. Arch Dis Child 88:688–694PubMedCentralPubMedCrossRef Wheeler D, Vimalachandra D, Hodson EM, Roy KLP, Smith G, Craig JC (2003) Antibiotics and surgery for VUR: a meta-analysis of randomised controlled trials. Arch Dis Child 88:688–694PubMedCentralPubMedCrossRef
38.
go back to reference Le Saux N, Pham Ba’, Moher D (2000) Evaluating the benefits of antimicrobial prophylaxis to prevent urinary tract infections in children: a systematic review. CMAJ 163:523–529 Le Saux N, Pham Ba’, Moher D (2000) Evaluating the benefits of antimicrobial prophylaxis to prevent urinary tract infections in children: a systematic review. CMAJ 163:523–529
39.
go back to reference Jodal U (1994) Aspects of clinical trials of drug efficacy in children with uncomplicated infections. Infection 22: S10–S11PubMedCrossRef Jodal U (1994) Aspects of clinical trials of drug efficacy in children with uncomplicated infections. Infection 22: S10–S11PubMedCrossRef
40.
go back to reference Reddy PP, Evans MT, Hughes PA, Dangman B, Cooper J, Lepow ML, Calvano CJ, Mandell J, (1997) Antimicrobial prophylaxis in children with vesico-ureteral reflux: a randomized prospective study of continuous therapy vs intermittent therapy vs surveillance Pediatrics 100 [Suppl]:555 Reddy PP, Evans MT, Hughes PA, Dangman B, Cooper J, Lepow ML, Calvano CJ, Mandell J, (1997) Antimicrobial prophylaxis in children with vesico-ureteral reflux: a randomized prospective study of continuous therapy vs intermittent therapy vs surveillance Pediatrics 100 [Suppl]:555
41.
go back to reference Ransley PG, Dhillon HK, Gordon I, Duffy PG, Dillon MJ, Barratt TM (1990) The postnatal management of hydronephrosis diagnosed by prenatal ultrasound. J Urol 144:584–587PubMed Ransley PG, Dhillon HK, Gordon I, Duffy PG, Dillon MJ, Barratt TM (1990) The postnatal management of hydronephrosis diagnosed by prenatal ultrasound. J Urol 144:584–587PubMed
42.
go back to reference Madden NP, Thomas DF, Gordon AC, Arthur RJ, Irving HC, Smith SE (1993) Antenatally detected pelviureteric junction obstruction. Is non-operation safe? Br J Urol 68:305–310CrossRef Madden NP, Thomas DF, Gordon AC, Arthur RJ, Irving HC, Smith SE (1993) Antenatally detected pelviureteric junction obstruction. Is non-operation safe? Br J Urol 68:305–310CrossRef
43.
go back to reference Galloway A (1997) Prevention of urinary tract infection in patients with spinal cord injury—a microbiological review. Spinal Cord 35:198–204PubMedCrossRef Galloway A (1997) Prevention of urinary tract infection in patients with spinal cord injury—a microbiological review. Spinal Cord 35:198–204PubMedCrossRef
44.
go back to reference Biering-Sorensen F, Hoiby N, Nordenbo A, Ravnborg M, Bruun B, Rahm V (1994) Ciprofloxacin as prophylaxis for urinary tract infection: prospective, randomised, cross-over, placebo-controlled study in patients with spinal cord lesion. J Urol 151:105–108PubMed Biering-Sorensen F, Hoiby N, Nordenbo A, Ravnborg M, Bruun B, Rahm V (1994) Ciprofloxacin as prophylaxis for urinary tract infection: prospective, randomised, cross-over, placebo-controlled study in patients with spinal cord lesion. J Urol 151:105–108PubMed
45.
go back to reference Johnson HW, Anderson JD, Chambers GK, Arnold WJD, Irwin BJ, Brinton JR (1994) A short-term study of nitrofurantoin prophylaxis in children managed with clean intermittent catheterization. Pediatrics 93:752–755PubMed Johnson HW, Anderson JD, Chambers GK, Arnold WJD, Irwin BJ, Brinton JR (1994) A short-term study of nitrofurantoin prophylaxis in children managed with clean intermittent catheterization. Pediatrics 93:752–755PubMed
46.
go back to reference Kuhlemeier KV, Stover SL, Loyd LK (1985) Prophylactic antibacterial therapy for preventing urinary tract infections in spinal cord injury patients. J Urol 134:514–517PubMed Kuhlemeier KV, Stover SL, Loyd LK (1985) Prophylactic antibacterial therapy for preventing urinary tract infections in spinal cord injury patients. J Urol 134:514–517PubMed
47.
go back to reference Mohler JL, Cowen DL, Flanigan RC (1987) Suppression and treatment of urinary tract infection in patients with an intermittently catheterized neurogenic bladder. J Urol 138:336–340PubMed Mohler JL, Cowen DL, Flanigan RC (1987) Suppression and treatment of urinary tract infection in patients with an intermittently catheterized neurogenic bladder. J Urol 138:336–340PubMed
48.
go back to reference Morton SC, Shekelle PG, Adams JL, Bennett C, Dobkin BH, Montgomerie J, Vickrey BG (2002) Antimicrobial prophylaxis for urinary tract infection in persons with spinal cord dysfunction. Arch Phys Med Rehabil 83:129–138PubMedCrossRef Morton SC, Shekelle PG, Adams JL, Bennett C, Dobkin BH, Montgomerie J, Vickrey BG (2002) Antimicrobial prophylaxis for urinary tract infection in persons with spinal cord dysfunction. Arch Phys Med Rehabil 83:129–138PubMedCrossRef
49.
go back to reference Nicolle LE (1992) Prophylaxis: recurrent urinary tract infection in women. Infection 20: S203–S205PubMedCrossRef Nicolle LE (1992) Prophylaxis: recurrent urinary tract infection in women. Infection 20: S203–S205PubMedCrossRef
50.
go back to reference Gupta K, Stamm WE (1999) Pathogenesis and management of recurrent urinary tract infections in women. World J Urol 17:415–420PubMedCrossRef Gupta K, Stamm WE (1999) Pathogenesis and management of recurrent urinary tract infections in women. World J Urol 17:415–420PubMedCrossRef
51.
go back to reference Nicolle LE, Ronald AR (1998) Recurrent urinary tract infection and its prevention. In: Brumfitt W, Hamilton-Miller JMT, Bailey RR (eds) Urinary tract infections. Chapman and Hall, Cambridge, UK, pp 293–301 Nicolle LE, Ronald AR (1998) Recurrent urinary tract infection and its prevention. In: Brumfitt W, Hamilton-Miller JMT, Bailey RR (eds) Urinary tract infections. Chapman and Hall, Cambridge, UK, pp 293–301
52.
go back to reference Stapleton A, Stamm WE (1997) Prevention of urinary tract infection. Infect Dis Clin North Am 11:719–734PubMedCrossRef Stapleton A, Stamm WE (1997) Prevention of urinary tract infection. Infect Dis Clin North Am 11:719–734PubMedCrossRef
53.
go back to reference Rubin RH, Shapiro ED, Andriole VT, Davis RJ, Stamm WE (1992) Evaluation of new anti-infective drugs for the treatment of urinary tract infection. Infectious Diseases Society of America and the Food and Drug Administration. Clin Infect Dis 15 [Suppl 1]:S216–S227 Rubin RH, Shapiro ED, Andriole VT, Davis RJ, Stamm WE (1992) Evaluation of new anti-infective drugs for the treatment of urinary tract infection. Infectious Diseases Society of America and the Food and Drug Administration. Clin Infect Dis 15 [Suppl 1]:S216–S227
54.
go back to reference Albert X, Huertas I, Pereiro I, Sanfelix J, Gosalbes V, Perrota C (2004) Antibiotics for preventing recurrent urinary tract infection in non-pregnant women (Cochrane Review). In: The Cochrane Library, Issue 3. Wiley, Chichester, UK Albert X, Huertas I, Pereiro I, Sanfelix J, Gosalbes V, Perrota C (2004) Antibiotics for preventing recurrent urinary tract infection in non-pregnant women (Cochrane Review). In: The Cochrane Library, Issue 3. Wiley, Chichester, UK
55.
go back to reference Brumfitt W, Hamilton-Miller JMT (1998) Efficacy and safety profile of long-term nitrofurantoin in urinary infections: 18 years’ experience. J Antimicrob Chemother 42:363–371PubMedCrossRef Brumfitt W, Hamilton-Miller JMT (1998) Efficacy and safety profile of long-term nitrofurantoin in urinary infections: 18 years’ experience. J Antimicrob Chemother 42:363–371PubMedCrossRef
56.
go back to reference Miller T, Phillips S (1981) Pyelonephritis: the relationship between infection, renal scarring, and antimicrobial therapy. Kidney Int 19:654–662PubMedCrossRef Miller T, Phillips S (1981) Pyelonephritis: the relationship between infection, renal scarring, and antimicrobial therapy. Kidney Int 19:654–662PubMedCrossRef
57.
go back to reference Winberg J (1994) Management of primary VUR in children—operation ineffective in preventing progressive renal damage. Infection 22 [Suppl 1]:4–7 Winberg J (1994) Management of primary VUR in children—operation ineffective in preventing progressive renal damage. Infection 22 [Suppl 1]:4–7
58.
go back to reference Hoberman A, Charran M, Hickey R, Baskin M, Kearney DH, Wald ER (2003) Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med 348:251CrossRef Hoberman A, Charran M, Hickey R, Baskin M, Kearney DH, Wald ER (2003) Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med 348:251CrossRef
59.
go back to reference Smellie J, Edwards D, Hunter N, Normand ICS, Prescod N (1975) VUR and renal scarring. Kidney Int 8:65–72CrossRef Smellie J, Edwards D, Hunter N, Normand ICS, Prescod N (1975) VUR and renal scarring. Kidney Int 8:65–72CrossRef
60.
go back to reference Merrick MV, Notghi A, Chalmers N, Wilkinson AG, Uttley WS (1995) Long-term follow-up to determine the prognostic value of imaging after urinary tract infections. Part 2: Scarring. Arch Dis Child 72:393–396PubMedCentralPubMedCrossRef Merrick MV, Notghi A, Chalmers N, Wilkinson AG, Uttley WS (1995) Long-term follow-up to determine the prognostic value of imaging after urinary tract infections. Part 2: Scarring. Arch Dis Child 72:393–396PubMedCentralPubMedCrossRef
61.
go back to reference Brendstrup L, Hjelt K, Petersen KE, Petersen S, Andersen EA, Daugbjerg PS, Stagegaard BR, Nielsen OH, Vejlsgaard R, Schou G (1990) Nitrofurantoin versus trimethoprim prophylaxis in recurrent urinary tract infection in children. Acta Paediatr Scand 79:1225–1234PubMedCrossRef Brendstrup L, Hjelt K, Petersen KE, Petersen S, Andersen EA, Daugbjerg PS, Stagegaard BR, Nielsen OH, Vejlsgaard R, Schou G (1990) Nitrofurantoin versus trimethoprim prophylaxis in recurrent urinary tract infection in children. Acta Paediatr Scand 79:1225–1234PubMedCrossRef
62.
go back to reference Holmberg L, Bowman G, Bottiger LE et al (1980) Adverse reactions to nitrofurantoin: analysis of 921 reports. Am J Med 69:733–738PubMedCrossRef Holmberg L, Bowman G, Bottiger LE et al (1980) Adverse reactions to nitrofurantoin: analysis of 921 reports. Am J Med 69:733–738PubMedCrossRef
63.
go back to reference Coraggio MJ, Gross TP, Roscelli JD (1989) Nitrofurantoin toxicity in children. Pediatr Infect Dis J 8:163–165PubMed Coraggio MJ, Gross TP, Roscelli JD (1989) Nitrofurantoin toxicity in children. Pediatr Infect Dis J 8:163–165PubMed
64.
go back to reference Brumfitt W, Hamilton-Miller JMT (1995) A comparative trial of low-dose cefaclor and macrocrystalline nitrofurantoin in the prevention of recurrent urinary tract infection. Infection 23:99–102CrossRef Brumfitt W, Hamilton-Miller JMT (1995) A comparative trial of low-dose cefaclor and macrocrystalline nitrofurantoin in the prevention of recurrent urinary tract infection. Infection 23:99–102CrossRef
65.
go back to reference Thompson RH, Chen JJ, Pugach J, Naseer S, Steinhardt GF (2001) Cessation of prophylactic antibiotics for managing persistent vesicoureteral reflux. J Urol 168:1465CrossRef Thompson RH, Chen JJ, Pugach J, Naseer S, Steinhardt GF (2001) Cessation of prophylactic antibiotics for managing persistent vesicoureteral reflux. J Urol 168:1465CrossRef
66.
go back to reference Coulthard MG (2002) Do kidneys outgrow the risk of reflux nephropathy? Pediatr Nephrol 17:477–480PubMedCrossRef Coulthard MG (2002) Do kidneys outgrow the risk of reflux nephropathy? Pediatr Nephrol 17:477–480PubMedCrossRef
67.
go back to reference Coulthard MG, Flecknell P, Orr H, Manas D, O’Donnell M (2002) Renal scarring caused by VUR and urinary infection: a study in pigs. Pediatr Nephrol 17:481–484PubMedCrossRef Coulthard MG, Flecknell P, Orr H, Manas D, O’Donnell M (2002) Renal scarring caused by VUR and urinary infection: a study in pigs. Pediatr Nephrol 17:481–484PubMedCrossRef
69.
go back to reference Norrby SR (1992) Design of clinical trials in patients with urinary tract infections. Infection 20 [Suppl 3]: S181–S188 Norrby SR (1992) Design of clinical trials in patients with urinary tract infections. Infection 20 [Suppl 3]: S181–S188
70.
go back to reference Bollgren I (1999) Antibacterial prophylaxis in children with urinary tract infection. Acta Paediatr Suppl 431:48–52CrossRef Bollgren I (1999) Antibacterial prophylaxis in children with urinary tract infection. Acta Paediatr Suppl 431:48–52CrossRef
71.
go back to reference Kaneko K, Ohtomo Y, Shimizu T, Yamashiro Y, Yamataka A, Miyano T (2003) Antibiotic prophylaxis by low-dose cefaclor in children with vesicoureteral reflux. Pediatr nephrol 18:468–470PubMed Kaneko K, Ohtomo Y, Shimizu T, Yamashiro Y, Yamataka A, Miyano T (2003) Antibiotic prophylaxis by low-dose cefaclor in children with vesicoureteral reflux. Pediatr nephrol 18:468–470PubMed
72.
go back to reference Daschner F, Marget W (1975) Treatment of recurrent urinary tract infection in children. II. Compliance of parents and children with antibiotic therapy regimes. Acta Paediatr Scand 64:105–108PubMedCrossRef Daschner F, Marget W (1975) Treatment of recurrent urinary tract infection in children. II. Compliance of parents and children with antibiotic therapy regimes. Acta Paediatr Scand 64:105–108PubMedCrossRef
73.
go back to reference Westenfelder M, Vahlensieck W, Reinartz U (1987) Patient compliance and efficacy of low-dose long-term prophylaxis in patients with recurrent urinary tract infection. Chemioterapia [Suppl 2]:530–532 Westenfelder M, Vahlensieck W, Reinartz U (1987) Patient compliance and efficacy of low-dose long-term prophylaxis in patients with recurrent urinary tract infection. Chemioterapia [Suppl 2]:530–532
74.
go back to reference Montini G, Rigon L, Gobber D, Zuchetta P, Murer L et al on behalf of the IRIS (Italian Renal Infection Study) group (2004) A randomised controlled trial of antibiotic prophylaxis in children with a previous documented pyelonephritis. Pediatr Nephrol 19:C71CrossRef Montini G, Rigon L, Gobber D, Zuchetta P, Murer L et al on behalf of the IRIS (Italian Renal Infection Study) group (2004) A randomised controlled trial of antibiotic prophylaxis in children with a previous documented pyelonephritis. Pediatr Nephrol 19:C71CrossRef
75.
go back to reference Blumberg EA, Abruyn E (1997) Methods for the reduction of urinary tract infection. Curr Opin Urol 7:47–51CrossRef Blumberg EA, Abruyn E (1997) Methods for the reduction of urinary tract infection. Curr Opin Urol 7:47–51CrossRef
76.
go back to reference Mangiarotti P, Pizzini C, Fanos V (2000) Antibiotic prophylaxis in children with relapsing urinary tract infections: review. J Chemother 12:115–123PubMedCrossRef Mangiarotti P, Pizzini C, Fanos V (2000) Antibiotic prophylaxis in children with relapsing urinary tract infections: review. J Chemother 12:115–123PubMedCrossRef
Metadata
Title
May we go on with antibacterial prophylaxis for urinary tract infections?
Author
R. Beetz
Publication date
01-01-2006
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 1/2006
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-005-2083-6

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