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Pediatric Nephrology
Published in: Pediatric Nephrology 7/2013

01-07-2013 | Review

Maximising living donation with paediatric blood-group-incompatible renal transplantation

Authors: Nizam Mamode, Stephen D. Marks

Published in: Pediatric Nephrology | Issue 7/2013

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Abstract

Long-term outcomes for paediatric renal transplant recipients have improved over the last 20 years, with better patient and renal allograft survival. As paediatric renal transplantation programmes have increased over this timeframe, living donation has become the favoured modality for renal replacement therapy and is advocated pre-emptively in as many cases as possible. However, one of the main barriers historically to living donation has been ABO blood-group incompatibility, with the result that patients were listed to be on call for a deceased donor renal transplant. The clinical scenario has now changed so that donors and recipients for renal transplantation can be worked up and listed for paired exchange and/or living-related ABO blood-group-incompatible renal transplantation (ABOi). There is extensive data in adult practice, and increasing evidence in paediatric practice that the short- and medium-term outcomes for both patient and renal allograft survival for ABOi is equivalent to that of blood-group-compatible renal transplantation.
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Metadata
Title
Maximising living donation with paediatric blood-group-incompatible renal transplantation
Authors
Nizam Mamode
Stephen D. Marks
Publication date
01-07-2013
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 7/2013
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-012-2279-5

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