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Scoliosis and Spinal Disorders
Published in: Scoliosis and Spinal Disorders 1/2010

Open Access 01-09-2010 | Oral presentation

Matrix metalloproteinases (MMP’s) in the rat scoliotic intervertebral disc

Authors: Theodoros B Grivas, E Vasiliadis, L Khaldi, A Kaspiris, D Kletsas

Published in: Scoliosis and Spinal Disorders | Special Issue 1/2010

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Excerpt

The response of the intervertebral disc to asymmetric forces may accelerate degeneration through changes in the matrix. At a macroscopic level the disc sustains structural changes which may play a role in the progression of a scoliotic curve. At a molecular level, disc degeneration is the outcome of the action of matrix metalloproteases (MMPs), members of a family of enzymes responsible for the degradation of extracellular matrix components. In the present experimental study we measured in vivo the expression of MMP’s in a rat scoliotic intervertebral disc and studied the impact of the degree of the deformity on their production. …
Metadata
Title
Matrix metalloproteinases (MMP’s) in the rat scoliotic intervertebral disc
Authors
Theodoros B Grivas
E Vasiliadis
L Khaldi
A Kaspiris
D Kletsas
Publication date
01-09-2010
Publisher
BioMed Central
Published in
Scoliosis and Spinal Disorders / Issue Special Issue 1/2010
Electronic ISSN: 2397-1789
DOI
https://doi.org/10.1186/1748-7161-5-S1-O18

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