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BMC Medical Genetics

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Open Access 01-12-2010 | Research article

Matrix metalloproteinase-9gene polymorphisms in nasal polyposis

Authors: Ling-Feng Wang, Chen-Yu Chien, Chih-Feng Tai, Wen-Rei Kuo, Edward Hsi, Suh-Hang Hank Juo

Published in: BMC Medical Genetics | Issue 1/2010

Abstract

Background

Matrix metalloproteinase (MMP) is involved in the upper airway remodeling process. We hypothesized that genetic variants of the MMP-9 gene are associated with cases of chronic rhinosinusitis with nasal polyposis.

Methods

We conducted a case-control study where 203 cases of chronic rhinosinusitis with nasal polyposis and 730 controls were enrolled. Three tagging single nucleotide polymorphisms (SNPs) and one promoter functional SNP rs3918242 were selected. Hardy-Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated according to three inheritance modes. Haplotype analysis was also performed. Permutation was used to adjust for multiple testing.

Results

All four SNPs were in HWE. The T allele of promoter SNP rs3918242 was associated with chronic rhinosinusitis with nasal polyposis under the dominant (nominal p = 0.023, empirical p = 0.022, OR = 1.62) and additive models (nominal p= 0.012, empirical p = 0.011, OR = 1.60). The A allele of rs2274756 has a nominal p value of 0.034 under the dominant model and 0.020 under the additive model. Haplotype analysis including the four SNPs showed a global p value of 0.015 and the most significant haplotype had a p value of 0.0045. We did not see any SNP that was more significant in the recurrent cases.

Conclusions

We concluded that MMP-9 gene polymorphisms may influence susceptibility to the development of chronic rhinosinusitis with nasal polyposis in Chinese population.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2350/11/85/prepub

Title: Matrix metalloproteinase-9gene polymorphisms in nasal polyposis
Authors: Ling-Feng Wang
Chen-Yu Chien
Chih-Feng Tai
Wen-Rei Kuo
Edward Hsi
Suh-Hang Hank Juo
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: BMC Medical Genetics / Issue 1/2010
Electronic ISSN: 1471-2350
DOI: https://doi.org/10.1186/1471-2350-11-85

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Matrix metalloproteinase-9gene polymorphisms in nasal polyposis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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