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01-08-2008 | Developmental Epidemiology

Maternal smoking in prenatal and early postnatal life and the risk of respiratory tract infections in infancy. The Generation R study

Authors: Liesbeth Duijts, Vincent W. V. Jaddoe, Albert Hofman, Eric A. P. Steegers, Johan P. Mackenbach, Johan C. de Jongste, Henriëtte A. Moll

Published in: European Journal of Epidemiology | Issue 8/2008

Abstract

Objective To assess the associations of maternal smoking during pregnancy and in the postnatal period with respiratory tract infections in young infants. Methods This study was embedded in the Generation R Study, a population-based prospective cohort study from fetal life onwards. All data were assessed by questionnaires. Maternal smoking was assessed in pregnancy (no, stopped when pregnancy was known, continued during pregnancy) and at 6 months postnatally. Doctor-attended respiratory tract infections were recorded at the age of 6 months. The present analyses were based on 3,418 subjects. Results Continued maternal smoking during pregnancy was not associated with respiratory tract infections in young infants. Maternal smoking in the postnatal period showed a tendency for an increased risk of lower respiratory tract infections in infants (adjusted odds ratio (aOR) 1.61 (95% confidence interval: 0.99, 2.63)). Dose–response effects for maternal smoking during pregnancy or in the postnatal period on the risk of respiratory tract infections were not observed. In infants of mothers who smoked neither during pregnancy nor in the postnatal period, environmental smoking during pregnancy and in the postnatal period together was associated with upper respiratory tract infections (aOR 1.58 (95% CI: 1.07, 2.35)). Conclusions No effect of maternal smoking during pregnancy with respiratory tract infections was observed. Weak evidence for the association between maternal smoking in the postnatal period and lower respiratory tract infections were found. Exposure to non-maternal environmental smoking during pregnancy and in the postnatal period together increases the risk of upper respiratory tract infections in young infants.

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Title: Maternal smoking in prenatal and early postnatal life and the risk of respiratory tract infections in infancy. The Generation R study
Authors: Liesbeth Duijts
Vincent W. V. Jaddoe
Albert Hofman
Eric A. P. Steegers
Johan P. Mackenbach
Johan C. de Jongste
Henriëtte A. Moll
Publication date: 01-08-2008
Publisher: Springer Netherlands
Published in: European Journal of Epidemiology / Issue 8/2008
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-008-9264-0

At a glance: The STEP trials

Springer Medicine

Maternal smoking in prenatal and early postnatal life and the risk of respiratory tract infections in infancy. The Generation R study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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