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Archives of Gynecology and Obstetrics

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01-01-2018 | General Gynecology

Maternal pre-pregnancy obesity and the risk of macrosomia: a meta-analysis

Authors: Rui-xue Dai, Xiu-Jie He, Chuan-Lai Hu

Published in: Archives of Gynecology and Obstetrics | Issue 1/2018

Abstract

Purpose

The aim of our meta-analysis was to explore whether pre-pregnancy obesity is regarded as an important risk factor for predicting macrosomia or not.

Methods

Three databases were systematically reviewed and reference lists of relevant articles were checked. Meta-analysis of published cohort studies comparing whether pre-pregnancy obesity was associated with macrosomia and adjusting for potential confounding factors. Calculations of pooled estimates were conducted in random-effect model. Heterogeneity was tested by using Chi-square test and I ² statistics. Publication bias was estimated from Egger’s test (linear regression method) and Begg’s test (rank correlation method).

Results

Sixteen cohort studies met the inclusion criteria. The meta-analysis showed that pre-pregnancy obesity was associated with macrosomia as an important risk factor. The adjusted odds ratio was 1.93, 95% CI (1.65, 2.27) in random-effect model, stratified analyses showed no differences regarding different quality grade, definition of macrosomia, location of study and number of confounding factors adjusted for. There was no indication of a publication bias either from the result of Egger’s test or Begg’s test.

Conclusion

Our findings indicated that pre-pregnancy obesity should be considered as an important risk factor for macrosomia. The effect of pre-pregnancy obesity on macrosomia need to be carefully assessed and monitored.

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Title: Maternal pre-pregnancy obesity and the risk of macrosomia: a meta-analysis
Authors: Rui-xue Dai
Xiu-Jie He
Chuan-Lai Hu
Publication date: 01-01-2018
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 1/2018
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4573-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Maternal pre-pregnancy obesity and the risk of macrosomia: a meta-analysis

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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