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Archives of Gynecology and Obstetrics

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01-03-2014 | Maternal-Fetal Medicine

Maternal passive smoking during pregnancy and neural tube defects in offspring: a meta-analysis

Authors: Meng Wang, Zhi-Ping Wang, Meng Zhang, Zhong-Tang Zhao

Published in: Archives of Gynecology and Obstetrics | Issue 3/2014

Abstract

Purpose

This study aims to examine the association between maternal passive smoking during pregnancy and the occurrence of neural tube defects (NTDs) in offspring.

Methods

We retrieved studies published on the association between maternal passive smoking during pregnancy and the occurrence of NTDs in offspring. Meta-analysis was applied to calculate the pooled effect estimates and their 95 % confidence intervals (CIs) using data from 10 case–control studies. The publication bias was assessed by the Egger’s regression asymmetry test and Begg’s rank correlation test with Begg’s funnel plot.

Results

The pooled effect estimate of maternal passive smoking was 1.82 (95 % CI 1.46–2.27) for total NTDs; the effect estimates were 1.72 (95 % CI 1.44–2.06), 1.52 (95 % CI 1.29–1.79), and 2.32 (95 % CI 1.34–4.01) for NTDs subtypes of anencephaly, spina bifida and encephalocele, respectively. Stratified by geographic region of the studies, the pooled effect estimates were 2.11 (95 % CI 1.46–3.06), 1.65 (95 % CI 1.16–2.34), 1.25 (95 % CI 0.41–3.80) in China, USA and Iran, respectively.

Conclusions

This meta-analysis suggested that maternal passive smoking during pregnancy was associated with an increased risk of total NTDs and three NTDs subtypes in offspring. Specifically, the associations were also found to be significantly positive both in China and USA.

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Title: Maternal passive smoking during pregnancy and neural tube defects in offspring: a meta-analysis
Authors: Meng Wang
Zhi-Ping Wang
Meng Zhang
Zhong-Tang Zhao
Publication date: 01-03-2014
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 3/2014
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-013-2997-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Maternal passive smoking during pregnancy and neural tube defects in offspring: a meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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