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BMC Pregnancy and Childbirth
Published in: BMC Pregnancy and Childbirth 1/2016

Open Access 01-12-2016 | Research article

Maternal hepatitis B virus carrier status and pregnancy outcomes: a prospective cohort study

Authors: Ai-Ming Cui, Xiao-Yan Cheng, Jian-Guo Shao, Hai-Bo Li, Xu-Lin Wang, Yi Shen, Li-Jing Mao, Sheng Zhang, Hai-Yun Liu, Lei Zhang, Gang Qin

Published in: BMC Pregnancy and Childbirth | Issue 1/2016

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Abstract

Background

Infection with hepatitis B virus (HBV) in pregnant women may be a threat for both mothers and fetuses. This study was performed to explore the impact of maternal HBV carrier status on pregnancy outcomes.

Methods

We conducted a prospective cohort study at the Obstetrics & Gynecology Hospital of Nantong University between January 1, 2012 and September 30, 2015. A consecutive sample of 21,004 pregnant women, 513 asymptomatic HBV carriers and 20,491 non-HBV controls, was included in this study. The main outcomes of interest were selected pregnancy outcomes including miscarriage, stillbirth, preterm birth (PTB), gestational diabetes (GDM), intrahepatic cholestasis of pregnancy (ICP), preterm premature rupture of the membrane (PPROM), low birth weight (LBW), small for gestational age (SGA) and Apgar scores. The incidence of adverse pregnancy outcomes between asymptomatic HBV carriers and non-HBV controls were compared using the chi-square test and logistic regression. P values were two sided, and P <0.05 was considered to indicate statistical significance.

Results

The incidences of stillbirth, PTB, GDM, ICP, PPROM, LBW, and SGA were similar between the HBV carrier and non-HBV groups. The proportion of miscarriage was significantly higher among the HBV carriers than the controls (9.36 % vs 5.70 %; P <0.001). After using multivariate modelling to adjust for possible socio-demographical variables and obstetric complications, women with HBV carrier status were still more likely to have miscarriage (adjusted OR 1.71, 95 % CI 1.23–2.38). In addition, the incidences of other maternal and neonatal outcomes were similar between the two groups.

Conclusion

Maternal HBV carrier status may be an independent risk factor for miscarriage and careful surveillance is warranted.
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Metadata
Title
Maternal hepatitis B virus carrier status and pregnancy outcomes: a prospective cohort study
Authors
Ai-Ming Cui
Xiao-Yan Cheng
Jian-Guo Shao
Hai-Bo Li
Xu-Lin Wang
Yi Shen
Li-Jing Mao
Sheng Zhang
Hai-Yun Liu
Lei Zhang
Gang Qin
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2016
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-016-0884-1

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