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01-05-2017 | Brief Report

Mast cell sarcoma of the sternum, clonally related to an antecedent germ cell tumor with a novel D579del KIT mutation

Authors: Atsushi Yamashita, Tsuyoshi Saito, Keisuke Akaike, Atsushi Arakawa, Akihiko Yoshida, Kentaro Kikuchi, Masahiko Sugitani, Takashi Yao

Published in: Virchows Archiv | Issue 5/2017

Excerpt

Mastocytosis is a heterogeneous disease characterized by the accumulation of abnormal mast cells. The disease is classified as either cutaneous or systemic mastocytosis based on the site of mast cell accumulation [1]. Two forms of systemic mastocytosis are known, namely extracutaneous mastocytoma and mast cell sarcoma. Both form a localized mass in non-cutaneous organs. Mastocytomas are non-destructive and show a benign course, while mast cell sarcomas cause destructive proliferation and malignant progression. …

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Title: Mast cell sarcoma of the sternum, clonally related to an antecedent germ cell tumor with a novel D579del KIT mutation
Authors: Atsushi Yamashita
Tsuyoshi Saito
Keisuke Akaike
Atsushi Arakawa
Akihiko Yoshida
Kentaro Kikuchi
Masahiko Sugitani
Takashi Yao
Publication date: 01-05-2017
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 5/2017
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-017-2089-z

At a glance: The STEP trials

Springer Medicine

Mast cell sarcoma of the sternum, clonally related to an antecedent germ cell tumor with a novel D579del KIT mutation

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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