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International Journal of Public Health

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01-07-2015 | Original Article

Mashhad stroke and heart atherosclerotic disorder (MASHAD) study: design, baseline characteristics and 10-year cardiovascular risk estimation

Authors: Majid Ghayour-Mobarhan, Mohsen Moohebati, Habibollah Esmaily, Mahmoud Ebrahimi, Seyed Mohammad Reza Parizadeh, Ali Reza Heidari-Bakavoli, Mohammad Safarian, Naghmeh Mokhber, Mohsen Nematy, Hamidreza Saber, Maryam Mohammadi, Mohammad Sobhan Sheikh Andalibi, Gordon A. Ferns, Mahmoud Reza Azarpazhooh

Published in: International Journal of Public Health | Issue 5/2015

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Abstract

Objective

The Mashhad stroke and heart atherosclerotic disorder (MASHAD) study is a 10-year cohort study that aims to evaluate the impact of various genetic, environmental, nutritional and psychosocial risk factors on the incidence of cardiovascular events among an urban population in eastern Iran.

Methods

The MASHAD study comprises a cohort of 9704 individuals aged 35–65 years using a stratified cluster random sampling design. This cohort will be followed up until 2020, with follow-up examinations being undertaken every 3 years. Ten-year cardiovascular disease (CVD) risk estimation was determined using NCEP ATP III criteria.

Results

Overall, 88.4 % of women and 79.2 % of men (P < 0.001) had at least one lipid abnormality. The 10-year risk for CVD of <10, 10–20 and >20 % were observed to be 86.6, 11 and 2.5 %, respectively. Predicted risk of CVD > 10 % using the Framingham algorithm was considerably higher in men compared to women. Overall, 9.5 % [95 % confidence interval (CI) 8.9–10.1 %] of our subjects had prevalent CAD.

Conclusion

The prevalence of CVD risk factors within our population is high compared to Western countries, indicating the necessity for interventional risk modifications.

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Title: Mashhad stroke and heart atherosclerotic disorder (MASHAD) study: design, baseline characteristics and 10-year cardiovascular risk estimation
Authors: Majid Ghayour-Mobarhan
Mohsen Moohebati
Habibollah Esmaily
Mahmoud Ebrahimi
Seyed Mohammad Reza Parizadeh
Ali Reza Heidari-Bakavoli
Mohammad Safarian
Naghmeh Mokhber
Mohsen Nematy
Hamidreza Saber
Maryam Mohammadi
Mohammad Sobhan Sheikh Andalibi
Gordon A. Ferns
Mahmoud Reza Azarpazhooh
Publication date: 01-07-2015
Publisher: Springer Basel
Published in: International Journal of Public Health / Issue 5/2015
Print ISSN: 1661-8556
Electronic ISSN: 1661-8564
DOI: https://doi.org/10.1007/s00038-015-0679-6

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