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Clinical Orthopaedics and Related Research®

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01-02-2011 | Symposium: Papers Presented at the Hip Society Meetings 2010

Markers of Thrombin Generation During Resurfacing and Noncemented Total Hip Arthroplasty: A Pilot Study

Authors: Edwin P. Su, MD, Nikos Chatzoudis, MD, Vasileios Sioros, MD, George Go, BS, Nigel E. Sharrock, BMedSci, MB, ChB

Published in: Clinical Orthopaedics and Related Research® | Issue 2/2011

Abstract

Background

Hip resurfacing arthroplasty (HRA) could be associated with an increased risk of deep vein thrombosis (DVT) compared to traditional noncemented THA because it involves greater dissection, increased kinking and distortion of the femoral vessels, takes longer to perform, and involves insertion of some cement into the femur.

Questions/purposes

Does HRA lead to greater risk of thromboembolism compared with noncemented THA?

Methods

We prospectively studied 20 patients receiving HRA and 20 receiving THA. All patients were younger than 67 years old and were similar in height, weight, American Society of Anesthesiologists status, and gender mix. Patients undergoing HRA were younger (mean, 50 versus 59 years), their surgery was longer (mean, 87 versus 65 minutes), and they required more crystalloid during surgery (mean, 2160 versus 1662 mL). Radial artery blood samples were taken at six events during surgery and assayed for prothrombin fragment F1 + 2 and thrombin-antithrombin III complex (TAT) using enzyme-linked immunosorbent assays.

Results

We observed no differences in the intraoperative increases in F1 + 2 and TAT between the two groups and no differences in surgical events.

Conclusion

Based on these data, HRA and THA should have similar risk of thromboembolism as THA based on the parameters we measured.

Level of Evidence

Level I, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.

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Title: Markers of Thrombin Generation During Resurfacing and Noncemented Total Hip Arthroplasty: A Pilot Study
Authors: Edwin P. Su, MD
Nikos Chatzoudis, MD
Vasileios Sioros, MD
George Go, BS
Nigel E. Sharrock, BMedSci, MB, ChB
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: Clinical Orthopaedics and Related Research® / Issue 2/2011
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-010-1659-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Markers of Thrombin Generation During Resurfacing and Noncemented Total Hip Arthroplasty: A Pilot Study

Abstract

Background

Questions/purposes

Methods

Results

Conclusion

Level of Evidence

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Questions/purposes

Methods

Results

Conclusion

Level of Evidence

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