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International Ophthalmology

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01-12-2024 | Marfan Syndrome | Original Paper

Corneal biomechanics and their association with severity of lens dislocation in Marfan syndrome

Authors: Guangming Jin, Minjie Zou, Longhui Li, Zhenzhen Liu, Charlotte Young, Haotian Qi, Danying Zheng

Published in: International Ophthalmology | Issue 1/2024

Abstract

Purpose

To investigate corneal biomechanical properties and its associations with the severity of lens dislocation in patients with Marfan syndrome.

Methods

A total of 30 patients with Marfan syndrome and 30 age-, sex- and axial length (AL)—matched controls were recruited. Corneal biomechanical parameters of both groups were measured by CorVis ST and were compared between groups. Potential associations between corneal biomechanical parameters and severity of lens dislocation were also investigated.

Results

Lower applanation 1 velocity (A1V) (0.13 ± 0.004 vs. 0.15 ± 0.003, P = 0.016), shorter applanation 2 time (A2T)(22.64 ± 0.11 vs. 22.94 ± 0.11, P = 0.013), longer peak distance (PD) (5.03 ± 0.07 vs. 4.81 ± 0.05, P = 0.008), longer radius (R) of highest concavity (7.44 ± 0.16 vs. 6.93 ± 0.14, P = 0.012), greater Ambrosio relational thickness horizontal (ARTh) (603 ± 20 vs. 498 ± 12, P < 0.001), and integrated radius (IR) (8.32 ± 0.25 vs. 8.95 ± 0.21, P = 0.033) were detected among Marfan eyes compared with controls (all P < 0.05). Marfan individuals with more severe lens dislocation tended to have increased stiffness parameter as longer A1T, slower A1V, shorter A2T, slower application 2 velocity (A2V), smaller PD and smaller Distance Amplitude (DA) (P < 0.05).

Conclusion

Marfan patients were detected to have increased corneal stiffness compared with normal subjects. Corneal biomechanical parameters were significantly associated with the severity of lens dislocation in Marfan patients.

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Title: Corneal biomechanics and their association with severity of lens dislocation in Marfan syndrome
Authors: Guangming Jin
Minjie Zou
Longhui Li
Zhenzhen Liu
Charlotte Young
Haotian Qi
Danying Zheng
Publication date: 01-12-2024
Publisher: Springer Netherlands
Keyword: Marfan Syndrome
Published in: International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-024-03079-9

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Springer Medicine

Corneal biomechanics and their association with severity of lens dislocation in Marfan syndrome

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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