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01-09-2018 | Original Contribution

MAOA genotype influences neural response during an inhibitory task in adolescents with conduct disorder

Authors: Xiaoqiang Sun, Ren Ma, Yali Jiang, Yidian Gao, Qingsen Ming, Qiong Wu, Daifeng Dong, Xiang Wang, Shuqiao Yao

Published in: European Child & Adolescent Psychiatry | Issue 9/2018

Abstract

Conduct disorder (CD), a common psychiatric disorder in children and adolescents, is characterized by encroaching upon other rights and violations of age-appropriate social expectations repeatedly and persistently. Individuals with CD often have high aggressiveness and low inhibitory capacity. The monoamine oxidase A (MAOA) gene has long been associated with aggression. Effects of MAOA genotype on inhibitory control have been examined in general population. Several studies had revealed reduced activation in prefrontal areas, especially the anterior cingulate cortex (ACC), in low-expression MAOA (MAOA-L) allele carriers compared to high-expression MAOA (MAOA-H) allele carriers. However, little is known about its genetic risk influences on inhibitory processes in clinical samples. In this study, functional magnetic resonance imaging (fMRI) was administered to a sample of adolescent boys with CD during the performance of a GoStop task, 29 of whom carrying MAOA-L allele and 24 carrying MAOA-H allele. Relative to MAOA-H carriers, MAOA-L carriers in CD showed more pronounced deactivation in the precuneus, supplementary motor area (SMA) and dorsal anterior cingulate cortex (dACC). Deactivation within the default mode network (DMN) and inhibitory-related areas in MAOA-L carriers may be related to compensation for low sensitivity to inhibition and/or an atypical allocation of cognitive resources. The results suggested a possible neural mechanism through which MAOA affects inhibitory processes in a clinical sample.

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American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, WashingtonCrossRef

Buitelaar JK, Smeets KC, Herpers P, Scheepers F, Glennon J, Rommelse NNJ (2013) Conduct disorders. Eur Child Adolesc Psychiatry 22(S1):49–54. https://doi.org/10.1007/s00787-012-0361-y CrossRef

Blair RJ, Leibenluft E, Pine DS (2014) Conduct disorder and callous-unemotional traits in youth. N Engl J Med 371(23):2207–2216. https://doi.org/10.1056/NEJMra1315612 CrossRefPubMedPubMedCentral

Hyde LW, Shaw DS, Hariri AR (2013) Understanding youth antisocial behavior using neuroscience through a developmental psychopathology lens: review, integration, and directions for research. Dev Rev 33 (3). https://doi.org/10.1016/j.dr.2013.06.001 CrossRef

Wu Q, Zhang X, Dong D, Wang X, Yao S (2017) Altered spontaneous brain activity in adolescent boys with pure conduct disorder revealed by regional homogeneity analysis. Eur Child Adolesc Psychiatry 26(7):827–837. https://doi.org/10.1007/s00787-017-0953-7 CrossRefPubMed

Sterzer P, Stadler C, Krebs A, Kleinschmidt A, Poustka F (2005) Abnormal neural responses to emotional visual stimuli in adolescents with conduct disorder. Biol Psychiatry 57(1):7–15. https://doi.org/10.1016/j.biopsych.2004.10.008 CrossRefPubMed

Lockwood PL, Sebastian CL, McCrory EJ, Hyde ZH, Gu X, De Brito SA, Viding E (2013) Association of callous traits with reduced neural response to others’ pain in children with conduct problems. Curr Biol 23(10):901–905. https://doi.org/10.1016/j.cub.2013.04.018 CrossRefPubMedPubMedCentral

Decety J, Michalska KJ, Akitsuki Y, Lahey BB (2009) Atypical empathic responses in adolescents with aggressive conduct disorder: a functional MRI investigation. Biol Psychol 80(2):203–211. https://doi.org/10.1016/j.biopsycho.2008.09.004 CrossRefPubMed

Coccaro EF, McCloskey MS, Fitzgerald DA, Phan KL (2007) Amygdala and orbitofrontal reactivity to social threat in individuals with impulsive aggression. Biol Psychiatry 62(2):168–178. https://doi.org/10.1016/j.biopsych.2006.08.024 CrossRefPubMed

10.

Marsh AA, Finger EC, Fowler KA, Jurkowitz I, Schechter JC, Yu HH, Pine DS, Blair R (2011) Reduced amygdala–orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits. Psychiatry Res 194(3):279–286. https://doi.org/10.1016/j.pscychresns.2011.07.008 CrossRefPubMedPubMedCentral

11.

White SF, Pope K, Sinclair S, Fowler KA, Brislin SJ, Williams WC, Pine DS, Blair RJ (2013) Disrupted expected value and prediction error signaling in youths with disruptive behavior disorders during a passive avoidance task. Am J Psychiatry 170(3):315–323. https://doi.org/10.1176/appi.ajp.2012.12060840 CrossRefPubMedPubMedCentral

12.

Fairchild G, Hagan CC, Passamonti L, Walsh ND, Goodyer IM, Calder AJ (2014) Atypical neural responses during face processing in female adolescents with conduct disorder. J Am Acad Child Adolesc Psychiatry 53(6):677–687. https://doi.org/10.1016/j.jaac.2014.02.009 CrossRefPubMedPubMedCentral

13.

Dalwani MS, Tregellas JR, Andrews-Hanna JR, Mikulich-Gilbertson SK, Raymond KM, Banich MT, Crowley TJ, Sakai JT (2014) Default mode network activity in male adolescents with conduct and substance use disorder. Drug Alcohol Depend 134:242–250. https://doi.org/10.1016/j.drugalcdep.2013.10.009 CrossRefPubMed

14.

Finger EC, Marsh AA, Blair KS, Reid ME, Sims C, Ng P, Pine DS, Blair RJ (2011) Disrupted reinforcement signaling in the orbitofrontal cortex and caudate in youths with conduct disorder or oppositional defiant disorder and a high level of psychopathic traits. Am J Psychiatry 168(2):152–162. https://doi.org/10.1176/appi.ajp.2010.10010129 CrossRefPubMed

15.

Shih JC, Chen K, Ridd MJ (1999) Monoamine oxidase: from genes to behavior. Annu Rev Neurosci 22:197–217. https://doi.org/10.1146/annurev.neuro.22.1.197 CrossRefPubMedPubMedCentral

16.

Salvatore JE, Dick DM (2016) Genetic influences on conduct disorder. Neurosci Biobehav Rev. https://doi.org/10.1016/j.neubiorev.2016.06.034 CrossRefPubMedPubMedCentral

17.

Sabol SZ, Hu S, Hamer D (1998) A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 103(3):273–279CrossRefPubMed

18.

Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2002) Role of genotype in the cycle of violence in maltreated children. Science 297(5582):851–854. https://doi.org/10.1126/science.1072290 CrossRefPubMed

19.

Kim-Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW, Moffitt TE (2006) MAOA, maltreatment, and gene-environment interaction predicting children’s mental health: new evidence and a meta-analysis. Mol Psychiatry 11(10):903–913. https://doi.org/10.1038/sj.mp.4001851 CrossRefPubMed

20.

Frazzetto G, Di Lorenzo G, Carola V, Proietti L, Sokolowska E, Siracusano A, Gross C, Troisi A (2007) Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA genotype. PLos One 2(5):e486. https://doi.org/10.1371/journal.pone.0000486 CrossRefPubMedPubMedCentral

21.

Cicchetti D, Rogosch FA, Thibodeau EL (2012) The effects of child maltreatment on early signs of antisocial behavior: genetic moderation by tryptophan hydroxylase, serotonin transporter, and monoamine oxidase A genes. Dev Psychopathol 24(3):907–928. https://doi.org/10.1017/S0954579412000442 CrossRefPubMedPubMedCentral

22.

Byrd AL, Manuck SB (2014) MAOA, childhood maltreatment, and antisocial behavior: meta-analysis of a gene-environment interaction. Biol Psychiatry 75(1):9–17. https://doi.org/10.1016/j.biopsych.2013.05.004 CrossRefPubMed

23.

Ficks CA, Waldman ID (2014) Candidate genes for aggression and antisocial behavior: a meta-analysis of association studies of the 5HTTLPR and MAOA-uVNTR. Behav Genet 44(5):427–444. https://doi.org/10.1007/s10519-014-9661-y CrossRefPubMed

24.

Fan J, Fossella J, Sommer T, Wu Y, Posner MI (2003) Mapping the genetic variation of executive attention onto brain activity. Proc Natl Acad Sci USA 100(12):7406–7411. https://doi.org/10.1073/pnas.0732088100 CrossRefPubMedPubMedCentral

25.

Denson TF, Dobson-Stone C, Ronay R, von Hippel W, Schira MM (2014) A functional polymorphism of the MAOA gene is associated with neural responses to induced anger control. J Cogn Neurosci 26(7):1418–1427. https://doi.org/10.1162/jocn_a_00592 CrossRefPubMed

26.

Cerasa A, Gioia MC, Fera F, Passamonti L, Liguori M, Lanza P, Muglia M, Magariello A, Quattrone A (2008) Ventro-lateral prefrontal activity during working memory is modulated by MAO A genetic variation. Brain Res 1201:114–121. https://doi.org/10.1016/j.brainres.2008.01.048 CrossRefPubMed

27.

Meyer-Lindenberg A, Buckholtz JW, Kolachana B, Pezawas RHA, Blasi L, Wabnitz G, Honea A, Verchinski R, Callicott B, Egan JH, Mattay M, Weinberger V DR (2006) Neural mechanisms of genetic risk for impulsivity and violence in humans. Proc Natl Acad Sci USA 103(16):6269–6274. https://doi.org/10.1073/pnas.0511311103 CrossRefPubMedPubMedCentral

28.

Aron AR, Robbins TW, Poldrack RA (2004) Inhibition and the right inferior frontal cortex. Trends Cogn Sci 8(4):170–177. https://doi.org/10.1016/j.tics.2004.02.010 CrossRefPubMed

29.

Bari A, Robbins TW (2013) Inhibition and impulsivity: Behavioral and neural basis of response control. Prog Neurobiol 108:44–79. https://doi.org/10.1016/j.pneurobio.2013.06.005 CrossRefPubMed

30.

Herba CM, Tranah T, Rubia K, Yule W (2006) Conduct problems in adolescence: three domains of inhibition and effect of gender. Dev Neuropsychol 30(2):659–695. https://doi.org/10.1207/s15326942dn3002_2 CrossRefPubMed

31.

Dalley JW, Everitt BJ, Robbins TW (2011) Impulsivity, compulsivity, and top-down cognitive control. Neuron 69(4):680–694. https://doi.org/10.1016/j.neuron.2011.01.020 CrossRefPubMed

32.

Rubia K, Smith AB, Brammer MJ, Taylor E (2003) Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection. NeuroImage 20(1):351–358CrossRefPubMed

33.

Blair RJR, Veroude K, Buitelaar JK (2016) Neuro-cognitive system dysfunction and symptom sets: a review of fMRI studies in youth with conduct problems. Neurosc Biobehav Rev. https://doi.org/10.1016/j.neubiorev.2016.10.022 CrossRef

34.

Dosenbach NU, Visscher KM, Palmer ED, Miezin FM, Wenger KK, Kang HC, Burgund ED, Grimes AL, Schlaggar BL, Petersen SE (2006) A core system for the implementation of task sets. Neuron 50(5):799–812. https://doi.org/10.1016/j.neuron.2006.04.031 CrossRefPubMedPubMedCentral

35.

Sharp DJ, Bonnelle V, De Boissezon X, Beckmann CF, James SG, Patel MC, Mehta MA (2010) Distinct frontal systems for response inhibition, attentional capture, and error processing. Proc Natl Acad Sci 107(13):6106–6111. https://doi.org/10.1073/pnas.1000175107 CrossRefPubMedPubMedCentral

36.

Whelan R, Conrod PJ, Poline JB, Lourdusamy A, Banaschewski T, Barker GJ, Bellgrove MA, Buchel C, Byrne M, Cummins TD, Fauth-Buhler M, Flor H, Gallinat J, Heinz A, Ittermann B, Mann K, Martinot JL, Lalor EC, Lathrop M, Loth E, Nees F, Paus T, Rietschel M, Smolka MN, Spanagel R, Stephens DN, Struve M, Thyreau B, Vollstaedt-Klein S, Robbins TW, Schumann G, Garavan H (2012) Adolescent impulsivity phenotypes characterized by distinct brain networks. Nat Neurosci 15(6):920–925. https://doi.org/10.1038/nn.3092 CrossRefPubMed

37.

Rubia K, Halari R, Smith AB, Mohammed M, Scott S, Giampietro V, Taylor E, Brammer MJ (2008) Dissociated functional brain abnormalities of inhibition in boys with pure conduct disorder and in boys with pure attention deficit hyperactivity disorder. Am J Psychiatry 165(7):889–897. https://doi.org/10.1176/appi.ajp.2008.07071084 CrossRefPubMed

38.

Zhu Y, Ying K, Wang J, Su L, Chen J, Lin F, Cai D, Zhou M, Wu D, Guo C, Wang S (2014) Differences in functional activity between boys with pure oppositional defiant disorder and controls during a response inhibition task: a preliminary study. Brain Imaging Behav 8(4):588–597. https://doi.org/10.1007/s11682-013-9275-7 CrossRefPubMed

39.

Castellanos-Ryan N, Struve M, Whelan R, Banaschewski T, Barker GJ, Bokde AL, Bromberg U, Buchel C, Flor H, Fauth-Buhler M, Frouin V, Gallinat J, Gowland P, Heinz A, Lawrence C, Martinot JL, Nees F, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Schumann G, Garavan H, Conrod PJ (2014) Neural and cognitive correlates of the common and specific variance across externalizing problems in young adolescence. Am J Psychiatry 171(12):1310–1319. https://doi.org/10.1176/appi.ajp.2014.13111499 CrossRefPubMed

40.

Zhang J, Li B, Gao J, Shi H, Wang X, Jiang Y, Ming Q, Gao Y, Ma R, Yao S (2015) Impaired frontal-basal ganglia connectivity in male adolescents with conduct disorder. PLos One 10(12):e145011. https://doi.org/10.1371/journal.pone.0145011 CrossRef

41.

Passamonti L, Fera F, Magariello A, Cerasa A, Gioia MC, Muglia M, Nicoletti G, Gallo O, Provinciali L, Quattrone A (2006) Monoamine oxidase-A genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity. Biol Psychiatry 59(4):334–340. https://doi.org/10.1016/j.biopsych.2005.07.027 CrossRefPubMed

42.

Holz N, Boecker R, Buchmann AF, Blomeyer D, Baumeister S, Hohmann S, Jennen-Steinmetz C, Wolf I, Rietschel M, Witt SH, Plichta MM, Meyer-Lindenberg A, Schmidt MH, Esser G, Banaschewski T, Brandeis D, Laucht M (2016) Evidence for a sex-dependent maoa× childhood stress interaction in the neural circuitry of aggression. Cereb Cortex 26(3):904–914. https://doi.org/10.1093/cercor/bhu249 CrossRefPubMed

43.

Dougherty DM, Bjork JM, Harper RA, Marsh DM, Moeller FG, Mathias CW, Swann AC (2003) Behavioral impulsivity paradigms: a comparison in hospitalized adolescents with disruptive behavior disorders. J Child Psychol Psychiatry 44(8):1145–1157CrossRefPubMed

44.

Rubia K, Smith AB, Halari R, Matsukura F, Mohammad M, Taylor E, Brammer MJ (2009) Disorder-specific dissociation of orbitofrontal dysfunction in boys with pure conduct disorder during reward and ventrolateral prefrontal dysfunction in boys with pure ADHD during sustained attention. Am J Psychiatry 166(1):83–94. https://doi.org/10.1176/appi.ajp.2008.08020212 CrossRefPubMed

45.

Stevens MC, Haney-Caron E (2012) Comparison of brain volume abnormalities between ADHD and conduct disorder in adolescence. J Psychiatry Neurosci 37(6):389–398CrossRefPubMedPubMedCentral

46.

First M, Spitzer R, Gibbon M, Williams J (2002) Structured clinical interview for DSM-IV-TR axis I disorders—patient edition (SCID-I/P, 11/2002 revision). New York State Psychiatric Institute, New York

47.

Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9(1):97–113CrossRefPubMed

48.

Gong Y, Cai T (1993) Wechsler intelligence scale for children, Chinese revision (C-WISC). Map Press, Hunan

49.

Yao S, Yang H, Zhu X, Auerbach RP, Abela JR, Pulleyblank RW, Tong X (2007) An examination of the psychometric properties of the Chinese version of the Barratt Impulsiveness Scale, 11th version in a sample of Chinese adolescents. Percept Mot Skills 104(3 Pt 2):1169–1182. https://doi.org/10.2466/pms.104.4.1169-1182 CrossRefPubMed

50.

Zhang Y, Ming QS, Yi JY, Wang X, Chai QL, Yao SQ (2017) Gene–gene–environment interactions of serotonin transporter, monoamine oxidase a and childhood maltreatment predict aggressive behavior in Chinese adolescents. Front Behav Neurosci 11:17. https://doi.org/10.3389/fnbeh.2017.00017 CrossRefPubMedPubMedCentral

51.

Li B, Friston KJ, Liu J, Liu Y, Zhang G, Cao F, Su L, Yao S, Lu H, Hu D (2014) Impaired frontal-basal ganglia connectivity in adolescents with internet addiction. Sci Rep 4:5027. https://doi.org/10.1038/srep05027 CrossRefPubMedPubMedCentral

52.

Chumbley JR, Friston KJ (2009) False discovery rate revisited: FDR and topological inference using Gaussian random fields. NeuroImage 44(1):62–70. https://doi.org/10.1016/j.neuroimage.2008.05.021 CrossRefPubMed

53.

Woo CW, Krishnan A, Wager TD (2014) Cluster-extent based thresholding in fMRI analyses: pitfalls and recommendations. NeuroImage 91:412–419. https://doi.org/10.1016/j.neuroimage.2013.12.058 CrossRefPubMed

54.

Lu RB, Lee JF, Ko HC, Lin WW, Chen K, Shih JC (2002) No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan. Prog Neuropsychopharmacol Biol Psychiatry 26(3):457–461CrossRefPubMed

55.

Chambers CD, Bellgrove MA, Stokes MG, Henderson TR, Garavan H, Robertson IH, Morris AP, Mattingley JB (2006) Executive “brake failure” following deactivation of human frontal lobe. J Cogn Neurosci 18(3):444–455. https://doi.org/10.1162/089892906775990606 CrossRefPubMed

56.

Swick D, Ashley V, Turken U (2011) Are the neural correlates of stopping and not going identical? Quantitative meta-analysis of two response inhibition tasks. NeuroImage 56(3):1655–1665. https://doi.org/10.1016/j.neuroimage.2011.02.070 CrossRefPubMed

57.

Elton A, Gao W (2015) Task-positive functional connectivity of the default mode network transcends task domain. J Cogn Neurosci 27(12):2369–2381. https://doi.org/10.1162/jocn_a_00859 CrossRefPubMed

58.

Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci USA 102(27):9673–9678. https://doi.org/10.1073/pnas.0504136102 CrossRefPubMedPubMedCentral

59.

Buckner RL, Andrews-Hanna JR, Schacter DL (2008) The brain’s default network: anatomy, function, and relevance to disease. Ann NY Acad Sci 1124:1–38. https://doi.org/10.1196/annals.1440.011 CrossRefPubMed

60.

Cavanna AE, Trimble MR (2006) The precuneus: a review of its functional anatomy and behavioural correlates. Brain 129(Pt 3):564–583. https://doi.org/10.1093/brain/awl004 CrossRefPubMed

61.

Broyd SJ, Demanuele C, Debener S, Helps SK, James CJ, Sonuga-Barke EJ (2009) Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev 33(3):279–296. https://doi.org/10.1016/j.neubiorev.2008.09.002 CrossRefPubMed

62.

Vatansever D, Menon DK, Manktelow AE, Sahakian BJ, Stamatakis EA (2015) Default mode network connectivity during task execution. NeuroImage 122:96–104. https://doi.org/10.1016/j.neuroimage.2015.07.053 CrossRefPubMed

63.

Anticevic A, Cole MW, Murray JD, Corlett PR, Wang XJ, Krystal JH (2012) The role of default network deactivation in cognition and disease. Trends Cogn Sci 16(12):584–592. https://doi.org/10.1016/j.tics.2012.10.008 CrossRefPubMedPubMedCentral

64.

Bonnelle V, Ham TE, Leech R, Kinnunen KM, Mehta MA, Greenwood RJ, Sharp DJ (2012) Salience network integrity predicts default mode network function after traumatic brain injury. Proc Natl Acad Sci USA 109(12):4690–4695. https://doi.org/10.1073/pnas.1113455109 CrossRefPubMedPubMedCentral

65.

Passamonti L, Cerasa A, Gioia MC, Magariello A, Muglia M, Quattrone A, Fera F (2008) Genetically dependent modulation of serotonergic inactivation in the human prefrontal cortex. NeuroImage 40(3):1264–1273. https://doi.org/10.1016/j.neuroimage.2007.12.028 CrossRefPubMed

66.

Allman JM, Hakeem A, Erwin JM, Nimchinsky E, Hof P (2001) The anterior cingulate cortex. The evolution of an interface between emotion and cognition. Ann NY Acad Sci 935:107–117CrossRefPubMed

67.

Holz NE, Zohsel K, Laucht M, Banaschewski T, Hohmann S, Brandeis D (2016) Gene x environment interactions in conduct disorder: Implications for future treatments. Neurosci Biobehav Rev. https://doi.org/10.1016/j.neubiorev.2016.08.017 CrossRefPubMed

68.

Sheth SA, Mian MK, Patel SR, Asaad WF, Williams ZM, Dougherty DD, Bush G, Eskandar EN (2012) Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation. Nature 488(7410):218–221. https://doi.org/10.1038/nature11239 CrossRefPubMedPubMedCentral

69.

Heilbronner SR, Hayden BY (2016) Dorsal anterior cingulate cortex: a bottom-up view. Annu Rev Neurosci 39:149–170. https://doi.org/10.1146/annurev-neuro-070815-013952 CrossRefPubMedPubMedCentral

70.

Clemens B, Voss B, Pawliczek C, Mingoia G, Weyer D, Repple J, Eggermann T, Zerres K, Reetz K, Habel U (2015) Effect of MAOA genotype on resting-state networks in healthy participants. Cereb Cortex 25(7):1771–1781. https://doi.org/10.1093/cercor/bht366 CrossRefPubMed

71.

Varnas K, Halldin C, Hall H (2004) Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain. Hum Brain Mapp 22(3):246–260. https://doi.org/10.1002/hbm.20035 CrossRefPubMedPubMedCentral

72.

Friston KJ (2011) Functional and effective connectivity: a review. Brain Connect 1(1):13–36. https://doi.org/10.1089/brain.2011.0008 CrossRefPubMed

73.

Buckholtz JW, Meyer-Lindenberg A (2008) MAOA and the neurogenetic architecture of human aggression. Trends Neurosci 31(3):120–129. https://doi.org/10.1016/j.tins.2007.12.006 CrossRefPubMed

74.

Nilsson KW, Comasco E, Hodgins S, Oreland L, Aslund C (2014) Genotypes do not confer risk for delinquency but rather alter susceptibility to positive and negative environmental factors: gene-environment interactions of BDNF Val66Met, 5-HTTLPR, and MAOA-uVNTR [corrected]. Int J Neuropsychopharmacol 18 (5). https://doi.org/10.1093/ijnp/pyu107

75.

Benjamin D, Van Bakel I, Craig IW (2000) A novel expression based approach for assessing the inactivation status of human X-linked genes. Eur J Hum Genet 8(2):103–108. https://doi.org/10.1038/sj.ejhg.5200427 CrossRefPubMed

76.

Aslund C, Nordquist N, Comasco E, Leppert J, Oreland L, Nilsson KW (2011) Maltreatment, MAOA, and delinquency: sex differences in gene-environment interaction in a large population-based cohort of adolescents. Behav Genet 41(2):262–272. https://doi.org/10.1007/s10519-010-9356-y CrossRefPubMed

77.

Sjoberg RL, Nilsson KW, Wargelius HL, Leppert J, Lindstrom L, Oreland L (2007) Adolescent girls and criminal activity: role of MAOA-LPR genotype and psychosocial factors. Am J Med Genet B Neuropsychiatr Genet 144B(2):159–164. https://doi.org/10.1002/ajmg.b.30360 CrossRefPubMed

78.

Verhoeven FE, Booij L, Kruijt AW, Cerit H, Antypa N, Does W (2012) The effects of MAOA genotype, childhood trauma, and sex on trait and state-dependent aggression. Brain Behav 2(6):806–813. https://doi.org/10.1002/brb3.96 CrossRefPubMedPubMedCentral

Title: MAOA genotype influences neural response during an inhibitory task in adolescents with conduct disorder
Authors: Xiaoqiang Sun
Ren Ma
Yali Jiang
Yidian Gao
Qingsen Ming
Qiong Wu
Daifeng Dong
Xiang Wang
Shuqiao Yao
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: European Child & Adolescent Psychiatry / Issue 9/2018
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-018-1170-8

At a glance: The STEP trials

Springer Medicine

MAOA genotype influences neural response during an inhibitory task in adolescents with conduct disorder

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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