Skip to main content
Top
Published in: BMC Ophthalmology 1/2014

Open Access 01-12-2014 | Research article

Management of significant reactivation of old disciform scars in wet Age-Related Macular Degeneration

Authors: Rosa M Coco, Anna Sala-Puigdollers

Published in: BMC Ophthalmology | Issue 1/2014

Login to get access

Abstract

Background

Fibrotic disciform scars represent the end-stage of wet age-related macular degeneration (AMD) and ophthalmologists tend not to treat them. However, reactivation can occur resulting in further worsening of patients. The aim of this study is to describe the clinical outcomes of 10 patients with disciform scars from age-related macular degeneration (AMD) that have subsequently reactivated.

Methods

Indocyanine green angiography (ICG) was used to identify the active areas and these “hot spots” (HS) that were subsequently treated with focal laser photocoagulation.

Results

In 10 out of 11 patients with potential reactivation of an AMD scar, a treatable HS was found on the ICG at the border of the disciform scar. The identified HS was treated with focal laser photocoagulation. Post treatment these areas became inactive. However in 2 cases, reactivation occurred requiring retreatment a few months later.

Conclusions

AMD patients who are noted to have disciform scars that are increasing in size and signs of activation such as lipid exudation and subretinal haemorrhage should undergo ICG imaging to look for HS. These patients could benefit from focal laser to stabilize the disease and avoid complications and further peripheral visual loss. It is suspected that these patients may have the polypoidal subtype of AMD.
Appendix
Available only for authorised users
Literature
1.
go back to reference Parodi M, Cascavilla M, Papayannis A, Kontadakis D, Bandello F, Iacono P: Intravitreal bevacizumab in advanced-stage neovascular age-related macular degeneration with visual acuity lower than 20/200. Arch Ophthalmol. 2012, 130: 934-935.CrossRefPubMed Parodi M, Cascavilla M, Papayannis A, Kontadakis D, Bandello F, Iacono P: Intravitreal bevacizumab in advanced-stage neovascular age-related macular degeneration with visual acuity lower than 20/200. Arch Ophthalmol. 2012, 130: 934-935.CrossRefPubMed
2.
go back to reference American Academy of Ophthalmology Retina Panel: Preferred practice pattern® guidelines: age-related macular degeneration. 2011, San Francisco, CA: American Academy of Ophthalmology, Available at: http://www.aao.org/ppp American Academy of Ophthalmology Retina Panel: Preferred practice pattern® guidelines: age-related macular degeneration. 2011, San Francisco, CA: American Academy of Ophthalmology, Available at: http://​www.​aao.​org/​ppp
3.
go back to reference Treumer F, Roider J, Hillenkamp J: Long-term outcome of subretinal coapplication of rtPA and bevacizumab followed by repeated intravitreal anti-VEGF injections for neovascular AMD with submacular haemorrhage. Br J Ophthalmol. 2012, 96: 708-713.CrossRefPubMed Treumer F, Roider J, Hillenkamp J: Long-term outcome of subretinal coapplication of rtPA and bevacizumab followed by repeated intravitreal anti-VEGF injections for neovascular AMD with submacular haemorrhage. Br J Ophthalmol. 2012, 96: 708-713.CrossRefPubMed
4.
go back to reference Tennant MT, Borrillo JL, Regillo CD: Management of submacular hemorrhage. Ophthalmol Clin North Am. 2002, 15: 445-452.CrossRefPubMed Tennant MT, Borrillo JL, Regillo CD: Management of submacular hemorrhage. Ophthalmol Clin North Am. 2002, 15: 445-452.CrossRefPubMed
5.
go back to reference Googe JM, Hirose T, Apple DJ, Melgen S: Vitreous hemorrhage secondary to age-related macular degeneration. Surv Ophthalmol. 1987, 32: 123-130.CrossRefPubMed Googe JM, Hirose T, Apple DJ, Melgen S: Vitreous hemorrhage secondary to age-related macular degeneration. Surv Ophthalmol. 1987, 32: 123-130.CrossRefPubMed
6.
go back to reference Virgili B, Bini A: Laser photocoagulation for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2007, 18: CD004763- Virgili B, Bini A: Laser photocoagulation for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2007, 18: CD004763-
7.
go back to reference Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY, MARINA Study Group: Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006, 355: 1419-1431.CrossRefPubMed Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY, MARINA Study Group: Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006, 355: 1419-1431.CrossRefPubMed
8.
go back to reference Votruba M, Gregor Z: Neovascular age-related macular degeneration: present and future treatment options. Eye. 2001, 15: 424-429.CrossRefPubMed Votruba M, Gregor Z: Neovascular age-related macular degeneration: present and future treatment options. Eye. 2001, 15: 424-429.CrossRefPubMed
9.
go back to reference Bressler NM: Age-related macular degeneration is the leading cause of blindness. JAMA. 2004, 291: 1900-1901.CrossRefPubMed Bressler NM: Age-related macular degeneration is the leading cause of blindness. JAMA. 2004, 291: 1900-1901.CrossRefPubMed
10.
go back to reference Fernandes LH, Freund KB, Yannuzzi LA, Spaide RF, Huang SJ, Slakter JS, Sorenson JA: The nature of focal areas of hyperfluorescence or hot spots imaged with indocyanine green angiography. Retina. 2002, 22: 557-568.CrossRefPubMed Fernandes LH, Freund KB, Yannuzzi LA, Spaide RF, Huang SJ, Slakter JS, Sorenson JA: The nature of focal areas of hyperfluorescence or hot spots imaged with indocyanine green angiography. Retina. 2002, 22: 557-568.CrossRefPubMed
11.
go back to reference Karagiannis DA1, Soublis V, Kandarakis A: A case of polypoidal choroidal vasculopathy: periphery is equally important for such patients. Clin Interv Aging. 2009, 4: 315-317.CrossRefPubMedPubMedCentral Karagiannis DA1, Soublis V, Kandarakis A: A case of polypoidal choroidal vasculopathy: periphery is equally important for such patients. Clin Interv Aging. 2009, 4: 315-317.CrossRefPubMedPubMedCentral
12.
go back to reference Cho HJ1, Lee DW, Cho SW, Kim CG, Kim JW: Hemorrhagic complications after intravitreal ranibizumab injection for polypoidal choroidal vasculopathy. Can J Ophthalmol. 2012, 47: 170-175.CrossRefPubMed Cho HJ1, Lee DW, Cho SW, Kim CG, Kim JW: Hemorrhagic complications after intravitreal ranibizumab injection for polypoidal choroidal vasculopathy. Can J Ophthalmol. 2012, 47: 170-175.CrossRefPubMed
13.
go back to reference Hiramy Y, Tsujikawa A, Otani A, Yodoi Y, Aikawa H, Mandai M, Yoshimura N: Hemorrhagic complications after photodynamic therapy for polypoidal choroidal vasculopathy. Retina. 2007, 27: 335-341.CrossRef Hiramy Y, Tsujikawa A, Otani A, Yodoi Y, Aikawa H, Mandai M, Yoshimura N: Hemorrhagic complications after photodynamic therapy for polypoidal choroidal vasculopathy. Retina. 2007, 27: 335-341.CrossRef
14.
go back to reference Tilanus MA, Vaandrager W, Cuypers MH, Verbeek AM, Hoyng CB: Relationship between anticoagulant medication and massive intraocular hemorrhage in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2000, 238: 482-485.CrossRefPubMed Tilanus MA, Vaandrager W, Cuypers MH, Verbeek AM, Hoyng CB: Relationship between anticoagulant medication and massive intraocular hemorrhage in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2000, 238: 482-485.CrossRefPubMed
15.
go back to reference Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N: Association of lesión size and visual prognosis to polypoidal choroidal vasculopathy. Am J Ophthalmol. 2011, 151: 961-972.CrossRefPubMed Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N: Association of lesión size and visual prognosis to polypoidal choroidal vasculopathy. Am J Ophthalmol. 2011, 151: 961-972.CrossRefPubMed
16.
go back to reference Lee MW, Yeo I, Wong D, Ang CL: Argon laser photocoagulation for the treatment of polypoidal choroidal vasculopathy. Eye (Lond). 2009, 23: 145-148.CrossRef Lee MW, Yeo I, Wong D, Ang CL: Argon laser photocoagulation for the treatment of polypoidal choroidal vasculopathy. Eye (Lond). 2009, 23: 145-148.CrossRef
17.
go back to reference Yuzawa M, Mori R, Haruyama M: A study of laser photocoagulation for polypoidal choroidal vasculopathy. Jpn J Ophthalmol. 2003, 47: 379-384.CrossRefPubMed Yuzawa M, Mori R, Haruyama M: A study of laser photocoagulation for polypoidal choroidal vasculopathy. Jpn J Ophthalmol. 2003, 47: 379-384.CrossRefPubMed
18.
go back to reference Macular Photocoagulation Study Group: Persistent and recurrent neovascularization after krypton laser photocoagulation for neovascular lesions of age-related macular degeneration. Arch Ophthalmol. 1990, 92: 825-831. Macular Photocoagulation Study Group: Persistent and recurrent neovascularization after krypton laser photocoagulation for neovascular lesions of age-related macular degeneration. Arch Ophthalmol. 1990, 92: 825-831.
19.
go back to reference Schatz H, Madeira D, McDonald HR, Johnson RN: Progressive enlargement of laser scars following grid laser photocoagulation for difuse macular edema. Arch Ophthalmol. 1991, 109: 1549-1551.CrossRefPubMed Schatz H, Madeira D, McDonald HR, Johnson RN: Progressive enlargement of laser scars following grid laser photocoagulation for difuse macular edema. Arch Ophthalmol. 1991, 109: 1549-1551.CrossRefPubMed
20.
go back to reference Kaiser P, Brown DM, Zhang K, Hudson HL, Holz FG, Shapiro H, Schneider S, Acharya NR: Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results. Am J Ophthalmol. 2007, 144: 850-857.CrossRefPubMed Kaiser P, Brown DM, Zhang K, Hudson HL, Holz FG, Shapiro H, Schneider S, Acharya NR: Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results. Am J Ophthalmol. 2007, 144: 850-857.CrossRefPubMed
21.
go back to reference The CATT Research Group: Ranibizumab and Bevacizumab for Neovascular age-related macular degeneration. N Engl J Med. 2011, 364: 1897-1908.CrossRefPubMedCentral The CATT Research Group: Ranibizumab and Bevacizumab for Neovascular age-related macular degeneration. N Engl J Med. 2011, 364: 1897-1908.CrossRefPubMedCentral
22.
go back to reference Cousins SW, Bearelly S, Reinoso MA, Chi SL, Espinosa-Heidmann DG: Dynamic indocyanine Green angiography-guided focal termal laser treatment of fibrotic choroidal neovascularization. Graefes Arch Clin Exp Ophthalmol. 2008, 246: 1677-1683.CrossRefPubMed Cousins SW, Bearelly S, Reinoso MA, Chi SL, Espinosa-Heidmann DG: Dynamic indocyanine Green angiography-guided focal termal laser treatment of fibrotic choroidal neovascularization. Graefes Arch Clin Exp Ophthalmol. 2008, 246: 1677-1683.CrossRefPubMed
Metadata
Title
Management of significant reactivation of old disciform scars in wet Age-Related Macular Degeneration
Authors
Rosa M Coco
Anna Sala-Puigdollers
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2014
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/1471-2415-14-82

Other articles of this Issue 1/2014

BMC Ophthalmology 1/2014 Go to the issue