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International Journal of Colorectal Disease

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01-08-2014 | Review

Management of peritoneal carcinomatosis from colorectal cancer: review of the literature

Authors: Carlo Vallicelli, Davide Cavaliere, Fausto Catena, Federico Coccolini, Luca Ansaloni, Elia Poiasina, Hariscine K. Abongwa, Belinda De Simone, Laura Alberici, Massimo Framarini, Giorgio M. Verdecchia

Published in: International Journal of Colorectal Disease | Issue 8/2014

Abstract

Background

Today, we do not have a universally accepted evidence on how to treat peritoneal carcinomatosis (PC) from colorectal cancer (CRC) in international guidelines.

Methods

The present study is a review of the literature investigating current strategies to treat CRC PC.

Results

Despite the progresses of systemic chemotherapy, the presence of PC among patients with metastatic CRC reduces the overall survival to 30 %, and only 4 % of patients with PC from CRC treated are alive for 5 years. Many trials evaluate the combined treatment of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for CRC PC, suggesting a survival benefit in highly selected patients. Only one trial is randomized and presents some biases. The two main prognostic factors are Peritoneal Cancer Index (PCI) and completeness of cytoreduction score (CC score). There is no universal agreement on how to approach the synchronous presence of PC and liver metastasis with a curative intent during the same procedure. A growing interest among the scientific community has arisen about systematic second-look surgery and HIPEC treatment in high-risk patients.

Conclusion

Current evidences suggest that CRS and HIPEC might be beneficial in highly selected patients affected with PC from CRC. Anyway, today, there is a shortage of well-designed phase 3 trials.

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Title: Management of peritoneal carcinomatosis from colorectal cancer: review of the literature
Authors: Carlo Vallicelli
Davide Cavaliere
Fausto Catena
Federico Coccolini
Luca Ansaloni
Elia Poiasina
Hariscine K. Abongwa
Belinda De Simone
Laura Alberici
Massimo Framarini
Giorgio M. Verdecchia
Publication date: 01-08-2014
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 8/2014
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-014-1907-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Management of peritoneal carcinomatosis from colorectal cancer: review of the literature

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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