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01-06-2010 | Breast Oncology

Management of Operable Invasive Breast Cancer in Women Over the Age of 70: Long-Term Results of a Large-Scale Single-Institution Experience

Authors: Fatima Laki, MD, Youlia M. Kirova, MD, Alexia Savignoni, MD, Francois Campana, MD, Beatrice Levu, MD, Marc Estève, MD, Brigitte Sigal-Zafrani, MD, Thierry Dorval, MD, Bernard Asselain, MD, PhD, Remy J. Salmon, MD

Published in: Annals of Surgical Oncology | Issue 6/2010

Abstract

Background

The treatment of choice for elderly women with breast cancer remains controversial. This retrospective analysis of a cohort from a single institution was designed to evaluate whether such patients are really undertreated because of their age and to reappraise their usual management.

Methods

The characteristics of 538 patients aged ≥ 70 years with operable breast cancer, treated between 1995 and 1999, were retrospectively analyzed comparing patients aged 70 to 75 years (group I, n = 288), 75 to 80 years (group II, n = 156), and ≥ 80 years (group III, n = 94). Cause-specific survival, distant recurrence-free interval, and local control were estimated by the Kaplan-Meier method and compared by log rank test. Multivariate analysis used Cox regression.

Results

In group III, tumors were more frequently T2 than T1 (P < 0.0001) and estrogen receptor negative (P = 0.045) than in groups I and II. Surgery was performed in 94.6% of patients, breast-conserving in 72.1% (62% in group III; P = 0.0015) with axillary dissection in 89.2% (77% in group III; P = 0.0015); 100% received radiotherapy after lumpectomy (hypofractionated in 63% of group III; P < 0.0001). Adjuvant hormone therapy and chemotherapy were administered to 57 and 3.7% of patients, respectively. At 7 years, no difference in the three groups was observed for cause-specific survival (91% for group I, 89% for group II, 86% for group III) distant recurrence-free interval, and local control (>90%).

Conclusions

Elderly patients with operable breast cancer who are completely and correctly treated with realistic treatment options that are based on surgery and adjuvant radiotherapy have a similar chance of being cured as younger patients.

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Title: Management of Operable Invasive Breast Cancer in Women Over the Age of 70: Long-Term Results of a Large-Scale Single-Institution Experience
Authors: Fatima Laki, MD
Youlia M. Kirova, MD
Alexia Savignoni, MD
Francois Campana, MD
Beatrice Levu, MD
Marc Estève, MD
Brigitte Sigal-Zafrani, MD
Thierry Dorval, MD
Bernard Asselain, MD, PhD
Remy J. Salmon, MD
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 6/2010
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-010-0967-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Management of Operable Invasive Breast Cancer in Women Over the Age of 70: Long-Term Results of a Large-Scale Single-Institution Experience

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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